Role of progesterone in nonhuman primate implantation

Ov Slayden, Christopher S. Keator

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    Herein we review the morphological and physiological effects of estradiol and progesterone (P) on the nonhuman primate uterus. Progesterone action acts to prepare the endometrium for embryo implantation, which normally occurs only during a brief period in the mid-luteal phase of the menstrual cycle. During this window of implantation, P stimulates secretory morphological differentiation and suppresses estrogen receptor α (ERα), in the endometrial functionalis zone. Reduced endometrial ERα is a definitive physiological marker for the onset of endometrial receptivity in primates. These actions of P are specific for the functionalis zones, and P does not fully inhibit ERα in the glands of basalis zone of nonhuman primates. Paradoxically, during the secretory phase of the cycle, progesterone receptor (PR) is also reduced in the glandular epithelium of the progestin-responsive functionalis zone. Therefore, P action on the epithelium in the functionalis zone may be mediated by paracrine factors arising from the PR-positive cells in the stroma. Genomic analysis of the endometrium of women and nonhuman primates has revealed numerous secretory phase genes that may contribute to differentiation of the endometrium. However, the exact nature and function of these putative factors have been elusive. We propose that nonhuman primates, especially macaques, can provide a valuable animal model for experimentally testing the functional role of P-regulated genes on endometrial receptivity.

    Original languageEnglish (US)
    Pages (from-to)418-430
    Number of pages13
    JournalSeminars in Reproductive Medicine
    Volume25
    Issue number6
    DOIs
    StatePublished - Nov 2007

    Fingerprint

    Primates
    Progesterone
    Endometrium
    Estrogen Receptors
    Progesterone Receptors
    Epithelium
    Luteal Phase
    Macaca
    Progestins
    Genes
    Uterus
    Estradiol
    Animal Models

    Keywords

    • Endometrium
    • Macaque
    • Progesterone
    • Secretory differentiation

    ASJC Scopus subject areas

    • Endocrinology
    • Physiology
    • Obstetrics and Gynecology
    • Reproductive Medicine

    Cite this

    Role of progesterone in nonhuman primate implantation. / Slayden, Ov; Keator, Christopher S.

    In: Seminars in Reproductive Medicine, Vol. 25, No. 6, 11.2007, p. 418-430.

    Research output: Contribution to journalArticle

    Slayden, Ov ; Keator, Christopher S. / Role of progesterone in nonhuman primate implantation. In: Seminars in Reproductive Medicine. 2007 ; Vol. 25, No. 6. pp. 418-430.
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