Role of parasympathetic nerves and muscarinic receptors in allergy and asthma

Gregory D. Scott, Allison D. Fryer

Research output: Chapter in Book/Report/Conference proceedingChapter

34 Scopus citations

Abstract

Parasympathetic nerves control the symptoms and inflammation of allergic diseases primarily by signaling through peripheral muscarinic receptors. Parasympathetic signaling targets classic effector tissues such as airway smooth muscle and secretory glands and mediates acute symptoms of allergic disease such as airway narrowing and increased mucus secretion. In addition, parasympathetic signaling modulates inflammatory cells and non-neuronal resident cell types such as fibroblasts and smooth muscle contributing to chronic allergic inflammation and tissue remodeling. Importantly, muscarinic antagonists are experiencing a rebirth for the treatment of asthma and may be useful for treating other allergic diseases.

Original languageEnglish (US)
Title of host publicationAllergy and the Nervous System
EditorsJohn Bienenstock
Pages48-69
Number of pages22
DOIs
StatePublished - Dec 1 2012

Publication series

NameChemical Immunology and Allergy
Volume98
ISSN (Print)1660-2242
ISSN (Electronic)1662-2898

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Scott, G. D., & Fryer, A. D. (2012). Role of parasympathetic nerves and muscarinic receptors in allergy and asthma. In J. Bienenstock (Ed.), Allergy and the Nervous System (pp. 48-69). (Chemical Immunology and Allergy; Vol. 98). https://doi.org/10.1159/00033649822