Role of pancreatic enzymes in the development of multiple organ failure after shock

Darren J. Malinoski, Cristobol Barrios, Hubert D. Kim, Jose A. Acosta, Geert W. Schmid-Schonbein, Tony E. Hugli, Raul Coimbra, David B. Hoyt

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalJournal of Organ Dysfunction
Volume4
Issue number3
DOIs
StatePublished - Oct 21 2008
Externally publishedYes

Keywords

  • Inflammation
  • Pancreas
  • Pancreatic duct ligation
  • Proteases
  • Serine protease inhibitors
  • Shock

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Critical Care
  • Critical Care and Intensive Care Medicine

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