Role of pancreatic enzymes in the development of multiple organ failure after shock

Darren Malinoski, Cristobol Barrios, Hubert D. Kim, Jose A. Acosta, Geert W. Schmid-Schonbein, Tony E. Hugli, Raul Coimbra, David B. Hoyt

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalJournal of Organ Dysfunction
Volume4
Issue number3
DOIs
StatePublished - 2008
Externally publishedYes

Fingerprint

Multiple Organ Failure
Shock
Enzymes
Exocrine Pancreas
Gastrointestinal Tract
Pancreas

Keywords

  • Inflammation
  • Pancreas
  • Pancreatic duct ligation
  • Proteases
  • Serine protease inhibitors
  • Shock

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Critical Care
  • Physiology
  • Molecular Biology

Cite this

Malinoski, D., Barrios, C., Kim, H. D., Acosta, J. A., Schmid-Schonbein, G. W., Hugli, T. E., ... Hoyt, D. B. (2008). Role of pancreatic enzymes in the development of multiple organ failure after shock. Journal of Organ Dysfunction, 4(3), 161-167. https://doi.org/10.1080/17471060801925288

Role of pancreatic enzymes in the development of multiple organ failure after shock. / Malinoski, Darren; Barrios, Cristobol; Kim, Hubert D.; Acosta, Jose A.; Schmid-Schonbein, Geert W.; Hugli, Tony E.; Coimbra, Raul; Hoyt, David B.

In: Journal of Organ Dysfunction, Vol. 4, No. 3, 2008, p. 161-167.

Research output: Contribution to journalArticle

Malinoski, D, Barrios, C, Kim, HD, Acosta, JA, Schmid-Schonbein, GW, Hugli, TE, Coimbra, R & Hoyt, DB 2008, 'Role of pancreatic enzymes in the development of multiple organ failure after shock', Journal of Organ Dysfunction, vol. 4, no. 3, pp. 161-167. https://doi.org/10.1080/17471060801925288
Malinoski, Darren ; Barrios, Cristobol ; Kim, Hubert D. ; Acosta, Jose A. ; Schmid-Schonbein, Geert W. ; Hugli, Tony E. ; Coimbra, Raul ; Hoyt, David B. / Role of pancreatic enzymes in the development of multiple organ failure after shock. In: Journal of Organ Dysfunction. 2008 ; Vol. 4, No. 3. pp. 161-167.
@article{9375365152e0463ba45ad184d0e2cd8e,
title = "Role of pancreatic enzymes in the development of multiple organ failure after shock",
abstract = "The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.",
keywords = "Inflammation, Pancreas, Pancreatic duct ligation, Proteases, Serine protease inhibitors, Shock",
author = "Darren Malinoski and Cristobol Barrios and Kim, {Hubert D.} and Acosta, {Jose A.} and Schmid-Schonbein, {Geert W.} and Hugli, {Tony E.} and Raul Coimbra and Hoyt, {David B.}",
year = "2008",
doi = "10.1080/17471060801925288",
language = "English (US)",
volume = "4",
pages = "161--167",
journal = "Journal of Organ Dysfunction",
issn = "1747-1060",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Role of pancreatic enzymes in the development of multiple organ failure after shock

AU - Malinoski, Darren

AU - Barrios, Cristobol

AU - Kim, Hubert D.

AU - Acosta, Jose A.

AU - Schmid-Schonbein, Geert W.

AU - Hugli, Tony E.

AU - Coimbra, Raul

AU - Hoyt, David B.

PY - 2008

Y1 - 2008

N2 - The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

AB - The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

KW - Inflammation

KW - Pancreas

KW - Pancreatic duct ligation

KW - Proteases

KW - Serine protease inhibitors

KW - Shock

UR - http://www.scopus.com/inward/record.url?scp=53949110088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53949110088&partnerID=8YFLogxK

U2 - 10.1080/17471060801925288

DO - 10.1080/17471060801925288

M3 - Article

AN - SCOPUS:53949110088

VL - 4

SP - 161

EP - 167

JO - Journal of Organ Dysfunction

JF - Journal of Organ Dysfunction

SN - 1747-1060

IS - 3

ER -