Role of pancreatic enzymes in the development of multiple organ failure after shock

Darren J. Malinoski, Cristobol Barrios, Hubert D. Kim, Jose A. Acosta, Geert W. Schmid-Schonbein, Tony E. Hugli, Raul Coimbra, David B. Hoyt

    Research output: Contribution to journalReview article

    5 Scopus citations


    The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.

    Original languageEnglish (US)
    Pages (from-to)161-167
    Number of pages7
    JournalJournal of Organ Dysfunction
    Issue number3
    StatePublished - Oct 21 2008



    • Inflammation
    • Pancreas
    • Pancreatic duct ligation
    • Proteases
    • Serine protease inhibitors
    • Shock

    ASJC Scopus subject areas

    • Physiology
    • Molecular Biology
    • Critical Care
    • Critical Care and Intensive Care Medicine

    Cite this

    Malinoski, D. J., Barrios, C., Kim, H. D., Acosta, J. A., Schmid-Schonbein, G. W., Hugli, T. E., Coimbra, R., & Hoyt, D. B. (2008). Role of pancreatic enzymes in the development of multiple organ failure after shock. Journal of Organ Dysfunction, 4(3), 161-167.