Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

K. A. Neve, Riad Qanbar, Michel Bouvier

Research output: Contribution to journalReview articlepeer-review

199 Scopus citations


G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the human genome. They are subject to numerous post-translational modifications, including palmitoylation. This review highlights the dynamic nature of palmitoylation and its role in GPCR expression and function. The palmitoylation of other proteins involved in GPCR signaling, such as G-proteins, regulators of G-protein signaling, and G-protein-coupled receptor kinases, is also discussed.

Original languageEnglish (US)
Pages (from-to)1-33
Number of pages33
JournalPharmacology and Therapeutics
Issue number1
StatePublished - Jan 1 2003
Externally publishedYes


  • G-protein-coupled receptors (GPCRs)
  • G-proteins
  • Palmitoylation
  • Signaling

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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