Role of Neuronal Signal Input in the Down‐Regulation of Central Noradrenergic Receptor Function by Antidepressant Drugs

Aaron Janowsky, Larry R. Steranka, David D. Gillespie, Fridolin Sulser

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Abstract: Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down‐regulation by antidepressants of the noradrenergic cyclic AMP‐generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE‐receptor complex are prerequisites for inducing noradrenergic subsensitivity.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalJournal of neurochemistry
Volume39
Issue number1
DOIs
StatePublished - Jul 1982

Keywords

  • Desipramine
  • Iprindole
  • Locus coeruleus lesions
  • Norepinephrine receptor‐coupled adenylate cyclase system
  • Subsensitivity to norepinephrine

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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