Role of Neuronal Signal Input in the Down‐Regulation of Central Noradrenergic Receptor Function by Antidepressant Drugs

Aaron Janowsky; Larry R. Steranka; David D. Gillespie; Fridolin Sulser

doi:10.1111/j.1471-4159.1982.tb04739.x

Role of Neuronal Signal Input in the Down‐Regulation of Central Noradrenergic Receptor Function by Antidepressant Drugs

Aaron Janowsky, Larry R. Steranka, David D. Gillespie, Fridolin Sulser

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Abstract: Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down‐regulation by antidepressants of the noradrenergic cyclic AMP‐generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE‐receptor complex are prerequisites for inducing noradrenergic subsensitivity.

Original language	English (US)
Pages (from-to)	290-292
Number of pages	3
Journal	Journal of neurochemistry
Volume	39
Issue number	1
DOIs	https://doi.org/10.1111/j.1471-4159.1982.tb04739.x
State	Published - Jul 1982
Externally published	Yes

Keywords

Desipramine
Iprindole
Locus coeruleus lesions
Norepinephrine receptor‐coupled adenylate cyclase system
Subsensitivity to norepinephrine

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1982.tb04739.x

Cite this

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abstract = "Abstract: Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down‐regulation by antidepressants of the noradrenergic cyclic AMP‐generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE‐receptor complex are prerequisites for inducing noradrenergic subsensitivity.",

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AU - Sulser, Fridolin

PY - 1982/7

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AB - Abstract: Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down‐regulation by antidepressants of the noradrenergic cyclic AMP‐generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE‐receptor complex are prerequisites for inducing noradrenergic subsensitivity.

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Role of Neuronal Signal Input in the Down‐Regulation of Central Noradrenergic Receptor Function by Antidepressant Drugs

Abstract

Keywords

ASJC Scopus subject areas

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