Role of N-acetylcysteine in prevention of contrast-induced nephropathy after cardiovascular procedures

A meta-analysis

Deepika Misra, Keith Leibowtiz, Ramesh M. Gowda, Michael Shapiro, Ijaz A. Khan

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background: Contrast-induced nephropathy is one of the common causes of acute renal insufficiency after cardiovascular procedures. Hypothesis: The objective of this paper was to analyze the published data on the usefulness of N-acetylcysteine in the prevention of contrast-induced nephropathy after these procedures. Methods: Trials were selected if they were prospective, randomized, controlled, had selected patients with impaired renal function, used low-osmolality, nonionic contrast media intra-arterially, administered a total of four doses of N-acetylcysteine in addition to intravenous saline hydration, and had contrast-induced nephropathy as their primary outcome. Contrast-induced nephropathy was defined as an increase in serum creatinine concentration by >0.5 mg/dl or a 25% increase above baseline at or within 48 h post procedure. Meta-analysis was performed using the Fisher's Combined Test with a measure of effect size. The magnitude of the N-acetylcysteine effect was estimated using random-effects models. Homogeneity was evaluated using the chi-square test of homogeneity and standard Q statistic. Reporting bias was explored by the Rosenthal method. Results: The Fisher's Combined Test was significant at p

Original languageEnglish (US)
Pages (from-to)607-610
Number of pages4
JournalClinical Cardiology
Volume27
Issue number11
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Acetylcysteine
Meta-Analysis
Chi-Square Distribution
Acute Kidney Injury
Osmolar Concentration
Contrast Media
Creatinine
Kidney
Serum

Keywords

  • Cardiac catheterization
  • Contrast induced nephropathy
  • Coronary angiography
  • N-acetylcysteine
  • Percutanous coronary intervention
  • Radio contrast dyes
  • Renal failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Role of N-acetylcysteine in prevention of contrast-induced nephropathy after cardiovascular procedures : A meta-analysis. / Misra, Deepika; Leibowtiz, Keith; Gowda, Ramesh M.; Shapiro, Michael; Khan, Ijaz A.

In: Clinical Cardiology, Vol. 27, No. 11, 11.2004, p. 607-610.

Research output: Contribution to journalArticle

Misra, Deepika ; Leibowtiz, Keith ; Gowda, Ramesh M. ; Shapiro, Michael ; Khan, Ijaz A. / Role of N-acetylcysteine in prevention of contrast-induced nephropathy after cardiovascular procedures : A meta-analysis. In: Clinical Cardiology. 2004 ; Vol. 27, No. 11. pp. 607-610.
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