Role of MAIT cells in pulmonary bacterial infection

Nadine Hartmann, Melanie J. Harriff, Curtis P. McMurtrey, William H. Hildebrand, David M. Lewinsohn, Mitchell Kronenberg

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAIT cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalMolecular Immunology
Volume101
DOIs
StatePublished - Sep 2018

Keywords

  • Innate immunity
  • MAIT cells
  • MR1
  • Pulmonary infection

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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