Role of MAIT cells in pulmonary bacterial infection

Nadine Hartmann, Melanie Harriff, Curtis P. McMurtrey, William H. Hildebrand, David Lewinsohn, Mitchell Kronenberg

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAIT cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalMolecular Immunology
Volume101
DOIs
StatePublished - Sep 1 2018

Fingerprint

Bacterial Infections
Lung
Vitamin B Complex
Major Histocompatibility Complex
Mucosal-Associated Invariant T Cells
Cytokines
T-Lymphocytes
Infection
Population
Proteins

Keywords

  • Innate immunity
  • MAIT cells
  • MR1
  • Pulmonary infection

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Cite this

Role of MAIT cells in pulmonary bacterial infection. / Hartmann, Nadine; Harriff, Melanie; McMurtrey, Curtis P.; Hildebrand, William H.; Lewinsohn, David; Kronenberg, Mitchell.

In: Molecular Immunology, Vol. 101, 01.09.2018, p. 155-159.

Research output: Contribution to journalArticle

Hartmann, N, Harriff, M, McMurtrey, CP, Hildebrand, WH, Lewinsohn, D & Kronenberg, M 2018, 'Role of MAIT cells in pulmonary bacterial infection', Molecular Immunology, vol. 101, pp. 155-159. https://doi.org/10.1016/j.molimm.2018.06.270
Hartmann, Nadine ; Harriff, Melanie ; McMurtrey, Curtis P. ; Hildebrand, William H. ; Lewinsohn, David ; Kronenberg, Mitchell. / Role of MAIT cells in pulmonary bacterial infection. In: Molecular Immunology. 2018 ; Vol. 101. pp. 155-159.
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