Role of lymphatic vessels in tumor immunity: Passive conduits or active participants?

Amanda Lund, Melody A. Swartz

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, the lymphatic system comprises a highly dynamic conduit system that regulates fluid homeostasis, antigen transport and immune cell trafficking, which all play important roles in the progression and resolution of inflammation, autoimmune diseases, and cancer. This review presents emerging evidence that lymphatic vessels are active modulators of immunity, perhaps fine-tuning the response to adjust the balance between peripheral tolerance and immunity. This suggests that the tumor-associated lymphatic vessels and draining lymph node may be important in tumor immunity which in turn governs metastasis.

Original languageEnglish (US)
Pages (from-to)341-352
Number of pages12
JournalJournal of Mammary Gland Biology and Neoplasia
Volume15
Issue number3
DOIs
StatePublished - Sep 2010
Externally publishedYes

Fingerprint

Lymphatic Vessel Tumors
Immunity
Active Immunity
Tumor Escape
Neoplasm Metastasis
Peripheral Tolerance
Inflammation
Lymphatic System
Neoplasms
Lymphatic Vessels
Allergy and Immunology
Autoimmunity
Autoimmune Diseases
Homeostasis
Lymph Nodes
Antigens
Research

Keywords

  • Autoimmunity
  • Cancer
  • Inflammation
  • Lymph node
  • Lymphangiogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Role of lymphatic vessels in tumor immunity : Passive conduits or active participants? / Lund, Amanda; Swartz, Melody A.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 15, No. 3, 09.2010, p. 341-352.

Research output: Contribution to journalArticle

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