Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection

Elizabeth M. Dahly, Melanie B. Gillingham, Ziwen Guo, Sangita G. Murali, David W. Nelson, Jens J. Holst, Denise M. Ney

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


To elucidate the role of luminal nutrients and glucagon-like peptide-2 (GLP-2) in intestinal adaptation, rats were subjected to 70% midjejunoileal resection or ileal transection and were maintained with total parenteral nutrition (TPN) or oral feeding. TPN rats showed small bowel mucosal hyperplasia at 8 h through 7 days after resection, demonstrating that exogenous luminal nutrients are not essential for resection-induced adaptation when residual ileum and colon are present. Increased enterocyte proliferation was a stronger determinant of resection-induced mucosal growth in orally fed animals, whereas decreased apoptosis showed a greater effect in TPN animals. Resection induced significant transient increases in plasma bioactive GLP-2 during TPN, whereas resection induced sustained increases in plasma GLP-2 during oral feeding. Resection-induced adaptive growth in TPN and orally fed rats was associated with a significant positive correlation between increases in plasma bioactive GLP-2 and proglucagon mRNA expression in the colon of TPN rats and ileum of orally fed rats. These data support a significant role for endogenous GLP-2 in the adaptive response to mid-small bowel resection in both TPN and orally fed rats.

Original languageEnglish (US)
Pages (from-to)G670-G682
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Issue number4 47-4
StatePublished - Apr 1 2003
Externally publishedYes


  • Enterocyte proliferation and apoptosis
  • Glucagon-like peptide-2
  • Ileum
  • Parenteral nutrition
  • Proglucagon

ASJC Scopus subject areas

  • Physiology
  • Hepatology
  • Gastroenterology
  • Physiology (medical)


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