Role of insulin-like growth factor-1R system in colorectal carcinogenesis

Erin A. Donovan, Shivaani Kummar

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.

Original languageEnglish (US)
Pages (from-to)91-98
Number of pages8
JournalCritical Reviews in Oncology/Hematology
Volume66
Issue number2
DOIs
StatePublished - May 2008
Externally publishedYes

Keywords

  • Acromegaly
  • Anti-IGF therapy
  • Epidemiologic studies in cancer
  • Growth factors

ASJC Scopus subject areas

  • Hematology
  • Oncology

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