Role of infiltrated leucocytes in tumour growth and spread

Elaine Lin, J. W. Pollard

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.

Original languageEnglish (US)
Pages (from-to)2053-2058
Number of pages6
JournalBritish Journal of Cancer
Volume90
Issue number11
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Fingerprint

Tumor Microenvironment
Leukocytes
Growth
Neoplasms
Intercellular Signaling Peptides and Proteins
Peptide Hydrolases
Neoplasm Metastasis

Keywords

  • Angiogenesis
  • Leucocyte
  • Metastasis
  • Progression
  • Tumour

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Role of infiltrated leucocytes in tumour growth and spread. / Lin, Elaine; Pollard, J. W.

In: British Journal of Cancer, Vol. 90, No. 11, 01.06.2004, p. 2053-2058.

Research output: Contribution to journalArticle

Lin, Elaine ; Pollard, J. W. / Role of infiltrated leucocytes in tumour growth and spread. In: British Journal of Cancer. 2004 ; Vol. 90, No. 11. pp. 2053-2058.
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