Role of human immunodeficiency virus and cytomegalovirus in AIDS encephalitis

C. A. Wiley, Jay Nelson

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Approximately half of patients with advanced acquired immune deficiency syndrome (AIDS) develop a subcortical dementia. The brains of all autopsies on AIDS patients performed at UCSD between 1982 and 1986 (N = 93) were studied. Neuropathologic changes consistent with a viral encephalitis were present in 54 brains (58%). Human immunodeficiency virus (HIV) antigens were detected in 37 of the brains (40%), most frequently in macrophages, multinucleated giant cells, and endothelial cells. Cytomegalovirus (CMV) was detected in 31 of the brains (33%), 22 of which also contained HIV. Cellular localization of CMV antigens suggests that CMV disseminates to the central nervous system hematogenously where the virus can infect endothelial cells, glia, and neurons. While the temporal course of the appearance of these two viruses within the CNS is not clear, the common simultaneous occurrence of both viruses within the brains of AIDS patients suggests that in vivo interaction between them may play a role in the pathogenesis of AIDS-associated encephalitis. Given the significant neurologic symptoms described in AIDS patients, the paucity of viral antigens suggests a pathogenic mechanism of indirect CNS damage rather than direct viral infection.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalAmerican Journal of Pathology
Volume133
Issue number1
StatePublished - 1988
Externally publishedYes

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Encephalitis
Cytomegalovirus
Acquired Immunodeficiency Syndrome
HIV
Brain
Viruses
Endothelial Cells
Viral Encephalitis
Antigens
Viral Antigens
Virus Diseases
Giant Cells
Neurologic Manifestations
Neuroglia
Dementia
Autopsy
Central Nervous System
Macrophages
Neurons

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Role of human immunodeficiency virus and cytomegalovirus in AIDS encephalitis. / Wiley, C. A.; Nelson, Jay.

In: American Journal of Pathology, Vol. 133, No. 1, 1988, p. 73-81.

Research output: Contribution to journalArticle

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