Role of GPR39 in neurovascular homeostasis and disease

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5 Scopus citations

Abstract

GPR39, a member of the ghrelin family of G protein-coupled receptors, is zinc-responsive and contributes to the regulation of diverse neurovascular and neurologic functions. Accumulating evidence suggests a role as a homeostatic regulator of neuronal excitability, vascular tone, and the immune response. We review GPR39 structure, function, and signaling, including constitutive activity and biased signaling, and summarize its expression pattern in the central nervous system. We further discuss its recognized role in neurovascular, neurological, and neuropsychiatric disorders.

Original languageEnglish (US)
Article number8200
JournalInternational journal of molecular sciences
Volume22
Issue number15
DOIs
StatePublished - Aug 1 2021

Keywords

  • Biased agonist
  • Dementia
  • Depression
  • Eicosanoids
  • Epilepsy
  • GPR39
  • Vascular tone
  • Zinc

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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