Role of gastric antioxidant and anti-Helicobactor pylori activities in antiulcerogenic activity of plantain banana (Musa sapientum var. paradisiaca)

R. K. Goel, K. Sairam, Ch V. Rao, A. Raman

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Studies with plantain banana (Musa sapientum var. paradisiaca) have indicated its ulcer protective and healing activities through its predominant effect on various mucosal defensive factors [Sanyal et.al, Arch Int Pharmacodyn, 149 (1964) 393; 155 (1965) 244]. Oxidative stress and Helicobactor pylori colonization are considered to be important factors in the pathogenesis of gastric ulcers. In the present study methanolic extract of plantain banana pulp (BE) was evaluated for its (i) antiulcer and antioxidant activities in 2 hr cold restraint stress and (ii) anti-H.pylori activity in vitro. The extract (BE, 50 mg/kg, twice daily for 5 days) showed significant antiulcer effect and antioxidant activity in gastric mucosal homogenates, where it reversed the increase in ulcer index, lipid peroxidation and super oxide dismutase values induced by stress. However it did not produce any change in catalase values, which was significantly decreased by stress. Further, in the in vitro study, BE (0.32 - 1000 μg/ml) did not show any anti-H.pylori activity. The results suggest absence of anti-H.pyloric activity of methanolic extract of banana in vitro and its antioxidant activity may be involved in its ulcerprotective activity.

Original languageEnglish (US)
Pages (from-to)719-722
Number of pages4
JournalIndian Journal of Experimental Biology
Volume39
Issue number7
StatePublished - Jul 23 2001

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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