Role of fetal membranes in signaling of fetal maturation and parturition

Leslie Myatt, Kang Sun

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The fetal membranes fulfill several functions during pregnancy. In addition to containing the products of conception and amniotic fluid, they presumably have barrier functions and fulfill paracrine signaling functions between the maternal (decidual) and fetal compartments. As the membranes are in an ideal place to receive both maternal and fetal signals and transmit signals to uterine myometrium, there has been a specific focus on the role of membranes in the initiation and maintenance of parturition. In this review, we summarize the data obtained in our laboratories as well as the data reported in the literature particularly with regard to the synthesis of steroids and prostaglandins in the fetal membranes, in signaling fetal maturation and in parturition. The fetal membranes are a major site both of prostaglandin synthesis and of prostaglandin metabolism. In addition, the abundant expression of 11beta-hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts biologically inactive cortisone into active cortisol, in the fetal membranes may provide an extra-adrenal source of glucocorticoids for the fetal compartment during gestation. Accumulating evidence indicates that a positive feedback loop involving glucocorticoids, proinflammatory cytokines, prostaglandins, surfactant protein-A (SP-A) and 11βHSD1 is formed locally in human fetal membranes towards term or in preterm labor. This positive feedback loop would produce abundant biologically active glucocorticoids and prostaglandins in the fetal membranes or amniotic fluid, which would ultimately promote fetal organ maturation and initiate parturition.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalInternational Journal of Developmental Biology
Volume54
Issue number2-3
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Extraembryonic Membranes
Prostaglandins
Parturition
Glucocorticoids
Amniotic Fluid
Mothers
Paracrine Communication
11-beta-Hydroxysteroid Dehydrogenases
Pulmonary Surfactant-Associated Protein A
Pregnancy
Membranes
Myometrium
Premature Obstetric Labor
Cortisone
Hydrocortisone
Steroids
Maintenance
Cytokines

Keywords

  • Fetal membrane
  • Fetus
  • Glucocorticoid
  • Parturition
  • Prostaglandin

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology
  • Medicine(all)

Cite this

Role of fetal membranes in signaling of fetal maturation and parturition. / Myatt, Leslie; Sun, Kang.

In: International Journal of Developmental Biology, Vol. 54, No. 2-3, 2010, p. 545-553.

Research output: Contribution to journalArticle

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