Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections

T. I. Nicas, D. W. Frank, Peter Stenzel, J. D. Lile, B. H. Iglewski

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Exoenzyme S is an extracellular ADP-ribosyltransferase enzyme produced by Pseudomonas aeruginosa. Mutants of Pseudomonas aeruginosa deficient in this enzyme have been shown to have reduced virulence in infections of burned mice. The contribution of exoenzyme S to the pathogenesis of chronic lung infections with this organism was evaluated by examining the incidence of exoenzyme S production by Pseudomonas aeruginosa strains isolated from cystic fibrosis patients and comparing an exoenzyme S deficient mutant and its exoenzyme S producing parent in a rat chronic lung infection model. Of 51 isolates examined, 43 % produced detectable levels of exoenzyme S. While both the exoenzyme S deficient mutant and its parent strain were equally capable of colonizing and persisting in rat lungs, the exoenzyme S producing parent elicited a greater degree of lung damage. These data suggest that exoenzyme S contributes to the pathogenesis of chronic lung infections.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalEuropean Journal of Clinical Microbiology
Volume4
Issue number2
DOIs
StatePublished - Apr 1985

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Pseudomonas aeruginosa
Lung
Infection
ADP Ribose Transferases
exoenzyme S
Enzymes
Cystic Fibrosis
Virulence
Incidence

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. / Nicas, T. I.; Frank, D. W.; Stenzel, Peter; Lile, J. D.; Iglewski, B. H.

In: European Journal of Clinical Microbiology, Vol. 4, No. 2, 04.1985, p. 175-179.

Research output: Contribution to journalArticle

Nicas, T. I. ; Frank, D. W. ; Stenzel, Peter ; Lile, J. D. ; Iglewski, B. H. / Role of exoenzyme S in chronic Pseudomonas aeruginosa lung infections. In: European Journal of Clinical Microbiology. 1985 ; Vol. 4, No. 2. pp. 175-179.
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