Role of E2F1 in endoplasmic reticulum stress signaling

Kyung Mi Park, Dong Joon Kim, Sang Gi Paik, Soo Jung Kim, Young Il Yeom

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that E2Fl-/- murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). These results therefore indicate that E2F1 deficiency increases phosphorylation of eIF2α in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis. in E2F1 deficient cells is related to the high level of eIF2α phosphorylation.

Original languageEnglish (US)
Pages (from-to)356-359
Number of pages4
JournalMolecules and Cells
Volume21
Issue number3
StatePublished - Jun 30 2006
Externally publishedYes

Fingerprint

Endoplasmic Reticulum Stress
Eukaryotic Initiation Factor-2
Eukaryotic Initiation Factors
Thapsigargin
Phosphorylation
Apoptosis
DNA Damage
E2F1 Transcription Factor
Cell Cycle
Fibroblasts

Keywords

  • E2F1
  • Endoplasmic reticulum stress
  • Eukaryotic translation initiation factor 2α (eIF2α)
  • Thapsigargin

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Park, K. M., Kim, D. J., Paik, S. G., Kim, S. J., & Yeom, Y. I. (2006). Role of E2F1 in endoplasmic reticulum stress signaling. Molecules and Cells, 21(3), 356-359.

Role of E2F1 in endoplasmic reticulum stress signaling. / Park, Kyung Mi; Kim, Dong Joon; Paik, Sang Gi; Kim, Soo Jung; Yeom, Young Il.

In: Molecules and Cells, Vol. 21, No. 3, 30.06.2006, p. 356-359.

Research output: Contribution to journalArticle

Park, KM, Kim, DJ, Paik, SG, Kim, SJ & Yeom, YI 2006, 'Role of E2F1 in endoplasmic reticulum stress signaling', Molecules and Cells, vol. 21, no. 3, pp. 356-359.
Park KM, Kim DJ, Paik SG, Kim SJ, Yeom YI. Role of E2F1 in endoplasmic reticulum stress signaling. Molecules and Cells. 2006 Jun 30;21(3):356-359.
Park, Kyung Mi ; Kim, Dong Joon ; Paik, Sang Gi ; Kim, Soo Jung ; Yeom, Young Il. / Role of E2F1 in endoplasmic reticulum stress signaling. In: Molecules and Cells. 2006 ; Vol. 21, No. 3. pp. 356-359.
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