The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4 + T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4 + T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4 + T-cell decline and limits CD4 + T-cell repopulation, even with highly active antiretroviral therapy.
|Original language||English (US)|
|Number of pages||7|
|Journal||Current HIV/AIDS Reports|
|State||Published - Feb 2009|
ASJC Scopus subject areas
- Infectious Diseases