Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4 + T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4 + T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4 + T-cell decline and limits CD4 + T-cell repopulation, even with highly active antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalCurrent HIV/AIDS Reports
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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