Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4 + T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4 + T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4 + T-cell decline and limits CD4 + T-cell repopulation, even with highly active antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalCurrent HIV/AIDS Reports
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2009
Externally publishedYes

Fingerprint

Lymphoid Tissue
HIV-1
Collagen
T-Lymphocytes
Infection
Simian Immunodeficiency Virus
Opportunistic Infections
Highly Active Antiretroviral Therapy
Virus Diseases
Acquired Immunodeficiency Syndrome
Neoplasms

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections. / Estes, Jacob.

In: Current HIV/AIDS Reports, Vol. 6, No. 1, 01.02.2009, p. 29-35.

Research output: Contribution to journalReview article

@article{b66844d5d562489d8ef76ee14aaa7bfe,
title = "Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections",
abstract = "The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4 + T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4 + T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4 + T-cell decline and limits CD4 + T-cell repopulation, even with highly active antiretroviral therapy.",
author = "Jacob Estes",
year = "2009",
month = "2",
day = "1",
doi = "10.1007/s11904-009-0005-0",
language = "English (US)",
volume = "6",
pages = "29--35",
journal = "Current HIV/AIDS Reports",
issn = "1548-3568",
publisher = "Current Science, Inc.",
number = "1",

}

TY - JOUR

T1 - Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections

AU - Estes, Jacob

PY - 2009/2/1

Y1 - 2009/2/1

N2 - The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4 + T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4 + T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4 + T-cell decline and limits CD4 + T-cell repopulation, even with highly active antiretroviral therapy.

AB - The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4 + T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4 + T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4 + T-cell decline and limits CD4 + T-cell repopulation, even with highly active antiretroviral therapy.

UR - http://www.scopus.com/inward/record.url?scp=61449243795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61449243795&partnerID=8YFLogxK

U2 - 10.1007/s11904-009-0005-0

DO - 10.1007/s11904-009-0005-0

M3 - Review article

C2 - 19149994

AN - SCOPUS:61449243795

VL - 6

SP - 29

EP - 35

JO - Current HIV/AIDS Reports

JF - Current HIV/AIDS Reports

SN - 1548-3568

IS - 1

ER -