Role of circulating immune complexes in human secondary syphilis

Joseph L. Jorizzo, M. Carol McNeely, Robert E. Baughn, Alvin R. Solomon, Tito Cavallo, Edgar B. Smith

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Studies in animal models and in the glomerulonephritis of human secondary syphilis and results from in vitro assays have suggested a role for circulating immune complexes (CICs) in human secondary syphilis. Nine adult subjects with early secondary syphilis were studied. All patients tested had CICs on C1q-binding or Raji cell assays. Proteins previously described as Treponema pallidum-specific antigens were detected by radioimmunoblot techniques in CICs from all five subjects tested. Biopsy of early cutaneous lesions revealed immunoreactants (IgG, C3, and/or C1q) in three of nine subjects and treponemal antigen in six of eight subjects tested. Histamine was injected intradermally as a trap for CICs, and biopsy of these injection sites revealed immunoreactants in four of nine subjects and treponemal antigen in five of eight subjects tested. A neutrophilic vascular reaction consistent with CIC-mediated vessel damage was seen in three of nine lesions and six of nine histamine injection sites. Normal controls did not show these changes.

Original languageEnglish (US)
Pages (from-to)1014-1022
Number of pages9
JournalJournal of Infectious Diseases
Volume153
Issue number6
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Jorizzo, J. L., Carol McNeely, M., Baughn, R. E., Solomon, A. R., Cavallo, T., & Smith, E. B. (1986). Role of circulating immune complexes in human secondary syphilis. Journal of Infectious Diseases, 153(6), 1014-1022. https://doi.org/10.1093/infdis/153.6.1014