Role of CD8+ lymphocytes in control and clearance of measles virus infection of rhesus monkeys

Sallie R. Permar, Sherry A. Klumpp, Keith G. Mansfield, Woong Ki Kim, Darci A. Gorgone, Michelle A. Lifton, Kenneth C. Williams, Jörn E. Schmitz, Keith A. Reimann, Michael K. Axthelm, Fernando P. Polack, Diane E. Griffin, Norman L. Letvin

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    Abstract

    The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8+ cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8+ lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8+ lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8+ lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.

    Original languageEnglish (US)
    Pages (from-to)4396-4400
    Number of pages5
    JournalJournal of virology
    Volume77
    Issue number7
    DOIs
    StatePublished - Apr 1 2003

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    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

    Cite this

    Permar, S. R., Klumpp, S. A., Mansfield, K. G., Kim, W. K., Gorgone, D. A., Lifton, M. A., Williams, K. C., Schmitz, J. E., Reimann, K. A., Axthelm, M. K., Polack, F. P., Griffin, D. E., & Letvin, N. L. (2003). Role of CD8+ lymphocytes in control and clearance of measles virus infection of rhesus monkeys. Journal of virology, 77(7), 4396-4400. https://doi.org/10.1128/JVI.77.7.4396-4400.2003