Abstract
The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8+ cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8+ lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8+ lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8+ lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.
Original language | English (US) |
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Pages (from-to) | 4396-4400 |
Number of pages | 5 |
Journal | Journal of virology |
Volume | 77 |
Issue number | 7 |
DOIs | |
State | Published - Apr 2003 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology