Role of catecholamines in mediating fetal blood volume decrease during acute hypoxia

R. A. Brace, Cecilia Cheung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Hypoxia was induced in chronically characterized sheep fetuses at 133 days gestation (term = 145-150 days) by lowering the O2 content of air inspired by the ewe while supplementing with 1-3% CO2. Control fetal arterial oxygen tension (PO2) averaged 22.5 ± 0.4 (SE) mmHg. During 30 min of mild hypoxia (PO2 decrease 2 by 4.3 ± 0.7 mmHg. In fetuses with α- plus β-receptor blockade, no change in blood volume occurred during mild hypoxia even though PO2 decreased by 3.4 ± 0.5 mmHg. During severe hypoxia (PO2 decrease ≥ 6 mmHg), fetal blood volume decreased by 9.2 ± 1.4% and PO2 by 10.4 ± 0.4 mmHg in normal fetuses. After adrenergic receptor blockade, blood volume decreased by 7.6 ± 2.5% when PO2 decreased by 8.0 ± 0.8 mmHg. Fetal arterial and venous pressure were unchanged during mild hypoxia. Vascular pressures increased significantly during severe hypoxia in normal and blocked fetuses, but these were significantly delayed following adrenergic blockade. Thus, although the catecholamines appear to mediate the decrease in fetal blood volume during mild hypoxia, they appear to have little effect on the blood volume decrease that occurs during severe hypoxia. In addition, the changes in blood volume are not directly correlated with the changes in arterial and venous pressures.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume253
Issue number4
StatePublished - 1987
Externally publishedYes

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Blood Volume
Fetal Blood
Catecholamines
Fetus
Arterial Pressure
Venous Pressure
Hypoxia
Adrenergic Agents
Adrenergic Receptors
Blood Vessels
Sheep
Air
Oxygen
Pressure
Pregnancy

ASJC Scopus subject areas

  • Physiology

Cite this

Role of catecholamines in mediating fetal blood volume decrease during acute hypoxia. / Brace, R. A.; Cheung, Cecilia.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 253, No. 4, 1987.

Research output: Contribution to journalArticle

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