Role of capillaries in determining CBF reserve: New insights using myocardial contrast echocardiography

Ananda R. Jayaweera, Kevin Wei, Matthew Coggins, Jiang Ping Bin, Craig Goodman, Sanjiv Kaul

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

To define the role of capillaries in the control of coronary blood flow (CBF) reserve, we developed a model of the coronary circulation and evaluated experimental data in its context. Our model comprised three compartments connected in series (arterial, capillary, and venous), each with its own resistance. The resistance in each vascular compartment was derived from the model based on hemodynamic data obtained in nine dogs during baseline and stenosis, both at rest and during hyperemia. The capillary hydrostatic pressure was assumed to be constant in all stages. Although in the absence of stenosis, the contribution of capillaries to total myocardial vascular resistance was only 25 ± 5% at rest, it increased to 75 ± 14% during hyperemia, despite the total myocardial vascular resistance decreasing by 51 ± 13%. In the presence of a noncritical stenosis, total myocardial vascular resistance decreased by 22 ± 10% at rest, with no change in capillary resistance. During hyperemia, total myocardial vascular resistance increased by 58 ± 50% in the presence of the noncritical stenosis. In this situation, because arteriolar and venular resistances were already minimal, the increase in myocardial vascular resistance was due to increased capillary resistance, making it the predominant source (84 ± 8%) of total myocardial vascular resistance. Myocardial video intensity (VI) on myocardial contrast echocardiography (MCE), which reflects capillary blood volume, decreased distal to the stenosis during hyperemia. In the presence of a flow-limiting stenosis at rest, myocardial VI also decreased, indicating that decrease in CBF was associated with an increase in capillary resistance. Our findings also provide an alternative explanation for the critical coronary closing pressure. Thus, contrary to previously held notions, capillaries play a vital role in the regulation of CBF.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume277
Issue number6 46-6
StatePublished - Dec 1999
Externally publishedYes

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Vascular Resistance
Echocardiography
Pathologic Constriction
Capillary Resistance
Hyperemia
Coronary Circulation
Hydrostatic Pressure
Blood Volume
Blood Vessels
Hemodynamics
Dogs
Pressure

Keywords

  • Coronary blood flow reserve
  • Regulation of coronary blood flow

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Role of capillaries in determining CBF reserve : New insights using myocardial contrast echocardiography. / Jayaweera, Ananda R.; Wei, Kevin; Coggins, Matthew; Bin, Jiang Ping; Goodman, Craig; Kaul, Sanjiv.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 277, No. 6 46-6, 12.1999.

Research output: Contribution to journalArticle

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