@article{f5089795c0824f198a5cd1b6f8e4cc96,
title = "Role of apolipoprotein E in anxiety",
abstract = "Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses.",
author = "Jacob Raber",
note = "Funding Information: Raber Jacob raberj@ohsu.edu Venault Patrice Departments of Behavioral Neuroscience and Neurology, Division of Neuroscience Oregon National Primate Research Center (ONPRC) Oregon Health & Science University L470, 3181 SW Sam Jackson Park Road Portland, OR 97239 USA ohsu.edu 2007 10 07 2007 2007 20 11 2006 07 02 2007 2007 Copyright {\textcopyright} 2007 Jacob Raber. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in the adrenal gland. In addition, human apoE isoforms have differential effects on anxiety in adult mice lacking apoE and probable AD patients. Compared to wild-type mice, mice lacking apoE and apoE4 mice showed pathological alterations in the central nucleus of the amygdala, which is involved in regulation of anxiety. ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone. Understanding how apoE modulates measures of anxiety might help the developments of therapeutic targets to reduce or even prevent measures of anxiety in health and in dementing illnesses. http://dx.doi.org/10.13039/100000863 Ellison Medical Foundation AG-NS-0201 http://dx.doi.org/10.13039/100000002 National Institutes of Health R01 AG20904 http://dx.doi.org/10.13039/100000002 National Institutes of Health M01 RR000334 Alzheimer{\textquoteright}s Disease Center http://dx.doi.org/10.13039/100000049 National Institute on Aging P30 AG08017 ",
year = "2007",
doi = "10.1155/2007/91236",
language = "English (US)",
volume = "2007",
journal = "Neural Plasticity",
issn = "2090-5904",
publisher = "Hindawi Publishing Corporation",
}