TY - JOUR
T1 - Role of AbrB in Spo0A- and Spo0B-dependent utilization of a sporulation promoter in Bacillus subtilis
AU - Zuber, P.
AU - Losick, R.
PY - 1987
Y1 - 1987
N2 - Transcription of the Bacillus subtilis gene spoVG is induced at the onset of sporulation and is dependent on the products of the stage-0 regulatory genes spo0A, spo0B, and spo0H. We show here that the dependence of spoVG transcription on Spo0A and Spo0B (but not Spo0H) can be bypassed by a mutation at abrB, a previously identified locus at which mutations that suppress some of the phenotypes of spo0A are often located, or by a cis-acting mutations within the spoVG promoter. To explain the epistatis of abrB to spo0A and spo0B mutations, we propose that AbrB acts, directly or indirectly, to block transcription of spoVG and that Spo0A and Spo0B cause inactivation of the abrB gene product(s). Spo0A-Spo0B-dependent inactivation of AbrB could be general explanation for the pleiotropic effect of spo0A and spo0B mutations on B. subtilis gene expression.
AB - Transcription of the Bacillus subtilis gene spoVG is induced at the onset of sporulation and is dependent on the products of the stage-0 regulatory genes spo0A, spo0B, and spo0H. We show here that the dependence of spoVG transcription on Spo0A and Spo0B (but not Spo0H) can be bypassed by a mutation at abrB, a previously identified locus at which mutations that suppress some of the phenotypes of spo0A are often located, or by a cis-acting mutations within the spoVG promoter. To explain the epistatis of abrB to spo0A and spo0B mutations, we propose that AbrB acts, directly or indirectly, to block transcription of spoVG and that Spo0A and Spo0B cause inactivation of the abrB gene product(s). Spo0A-Spo0B-dependent inactivation of AbrB could be general explanation for the pleiotropic effect of spo0A and spo0B mutations on B. subtilis gene expression.
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U2 - 10.1128/jb.169.5.2223-2230.1987
DO - 10.1128/jb.169.5.2223-2230.1987
M3 - Article
C2 - 2437099
AN - SCOPUS:0023272642
SN - 0021-9193
VL - 169
SP - 2223
EP - 2230
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 5
ER -