RNA directed DNA polymerase activity in Greene hamster melanoma

T. W. Reid, T. L. Darling, P. Russell, D. M. Albert

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

As part of a biochemical search for a virus in melanomas preliminary kinetic studies with RNA directed DNA polymerase from avian myeloblastosis virus showed that thymidine labeled triphosphate (TTP) stimulates the enzyme. This stimulatory effect was used as an additional probe in detecting RNA directed DNA polymerase activity in Greene hamster melanoma in vivo. This enzyme activity, however, was not found in the Greene hamster melanoma cells growing in tissue culture under ordinary conditions. When the cells were treated with BUDR the enzyme could be demonstrated and the stimulating effect of TTP was observed.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalYale Journal of Biology and Medicine
Volume46
Issue number5
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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