River blindness: Reducing the risk in at-risk populations

Joo M. Furtado, Kevin L. Winthrop, Frank O. Richards

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Onchocerciasis, an eye and skin disease caused by Onchocerca volvulus, is a leading cause of infectious blindness worldwide. Most onchocercal morbidity occurs in sub-Saharan Africa, while small disease foci exist within Latin America and Yemen. Disease control and elimination campaigns currently rely primarily on mass distribution of ivermectin, a therapy that does not cure the infection, but rather prevents the development of the eye and skin disease. Within Latin America, these strategies have dramatically reduced the incidence of new infection, and blindness attributable to onchocerciasis no longer exists in the region. Within Africa, decreases in ocular disease have also been documented. New therapeutic strategies targeting the endosymbiotic bacteria Wolbachia spp. are currently being evaluated in Africa.

Original languageEnglish (US)
Pages (from-to)33-41
Number of pages9
JournalExpert Review of Ophthalmology
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2011

Keywords

  • Africa
  • Latin America
  • blindness
  • doxycycline
  • filaria
  • ivermectin
  • microfilariae
  • onchocerciasis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology
  • Optometry

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