Risk of retinal neovascularization in cases of uveitis

Apurva K. Patel, Craig W. Newcomb, Teresa L. Liesegang, Siddharth S. Pujari, Eric Suhler, Jennifer E. Thorne, C. Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James (Jim) Rosenbaum, H. Nida Sen, Pichaporn Artornsombudh, Srishti Kothari, John H. Kempen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose To evaluate the risk of and risk factors for retinal neovascularization (NV) in cases of uveitis. Design Retrospective cohort study. Participants Patients with uveitis at 4 US academic ocular inflammation subspecialty practices. Methods Data were ascertained by standardized chart review. Prevalence data analysis used logistic regression. Incidence data analysis used survival analysis with time-updated covariates where appropriate. Main Outcome Measures Prevalence and incidence of NV. Results Among uveitic eyes of 8931 patients presenting for initial evaluation, 106 of 13 810 eyes had NV (prevalence = 0.77%, 95% confidence interval [CI], 0.60-0.90). Eighty-eight more eyes developed NV over 26 465 eye-years (incidence, 0.33%/eye-year; 95% CI, 0.27-0.41). Factors associated with incident NV include age 35 years (adjusted hazard ratio [aHR], 2.4; 95% CI, 1.5-3.9), current cigarette smoking (aHR, 1.9; 95% CI, 1.1-3.4), and systemic lupus erythematosus (aHR, 3.5, 95% CI, 1.1-11). Recent diagnosis of uveitis was associated with an increased incidence of NV (compared with patients diagnosed >5 years ago, aHR, 2.4 [95% CI, 1.1-5.0] and aHR, 2.6 [95% CI, 1.2-6.0] for diagnosis within

Original languageEnglish (US)
Pages (from-to)646-654
Number of pages9
JournalOphthalmology
Volume123
Issue number3
DOIs
StatePublished - Mar 1 2016

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Retinal Neovascularization
Uveitis
Confidence Intervals
Incidence
Survival Analysis
Systemic Lupus Erythematosus
Cohort Studies
Retrospective Studies
Logistic Models
Smoking
Outcome Assessment (Health Care)
Inflammation

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Patel, A. K., Newcomb, C. W., Liesegang, T. L., Pujari, S. S., Suhler, E., Thorne, J. E., ... Kempen, J. H. (2016). Risk of retinal neovascularization in cases of uveitis. Ophthalmology, 123(3), 646-654. https://doi.org/10.1016/j.ophtha.2015.10.056

Risk of retinal neovascularization in cases of uveitis. / Patel, Apurva K.; Newcomb, Craig W.; Liesegang, Teresa L.; Pujari, Siddharth S.; Suhler, Eric; Thorne, Jennifer E.; Foster, C. Stephen; Jabs, Douglas A.; Levy-Clarke, Grace A.; Nussenblatt, Robert B.; Rosenbaum, James (Jim); Sen, H. Nida; Artornsombudh, Pichaporn; Kothari, Srishti; Kempen, John H.

In: Ophthalmology, Vol. 123, No. 3, 01.03.2016, p. 646-654.

Research output: Contribution to journalArticle

Patel, AK, Newcomb, CW, Liesegang, TL, Pujari, SS, Suhler, E, Thorne, JE, Foster, CS, Jabs, DA, Levy-Clarke, GA, Nussenblatt, RB, Rosenbaum, JJ, Sen, HN, Artornsombudh, P, Kothari, S & Kempen, JH 2016, 'Risk of retinal neovascularization in cases of uveitis', Ophthalmology, vol. 123, no. 3, pp. 646-654. https://doi.org/10.1016/j.ophtha.2015.10.056
Patel AK, Newcomb CW, Liesegang TL, Pujari SS, Suhler E, Thorne JE et al. Risk of retinal neovascularization in cases of uveitis. Ophthalmology. 2016 Mar 1;123(3):646-654. https://doi.org/10.1016/j.ophtha.2015.10.056
Patel, Apurva K. ; Newcomb, Craig W. ; Liesegang, Teresa L. ; Pujari, Siddharth S. ; Suhler, Eric ; Thorne, Jennifer E. ; Foster, C. Stephen ; Jabs, Douglas A. ; Levy-Clarke, Grace A. ; Nussenblatt, Robert B. ; Rosenbaum, James (Jim) ; Sen, H. Nida ; Artornsombudh, Pichaporn ; Kothari, Srishti ; Kempen, John H. / Risk of retinal neovascularization in cases of uveitis. In: Ophthalmology. 2016 ; Vol. 123, No. 3. pp. 646-654.
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abstract = "Purpose To evaluate the risk of and risk factors for retinal neovascularization (NV) in cases of uveitis. Design Retrospective cohort study. Participants Patients with uveitis at 4 US academic ocular inflammation subspecialty practices. Methods Data were ascertained by standardized chart review. Prevalence data analysis used logistic regression. Incidence data analysis used survival analysis with time-updated covariates where appropriate. Main Outcome Measures Prevalence and incidence of NV. Results Among uveitic eyes of 8931 patients presenting for initial evaluation, 106 of 13 810 eyes had NV (prevalence = 0.77{\%}, 95{\%} confidence interval [CI], 0.60-0.90). Eighty-eight more eyes developed NV over 26 465 eye-years (incidence, 0.33{\%}/eye-year; 95{\%} CI, 0.27-0.41). Factors associated with incident NV include age 35 years (adjusted hazard ratio [aHR], 2.4; 95{\%} CI, 1.5-3.9), current cigarette smoking (aHR, 1.9; 95{\%} CI, 1.1-3.4), and systemic lupus erythematosus (aHR, 3.5, 95{\%} CI, 1.1-11). Recent diagnosis of uveitis was associated with an increased incidence of NV (compared with patients diagnosed >5 years ago, aHR, 2.4 [95{\%} CI, 1.1-5.0] and aHR, 2.6 [95{\%} CI, 1.2-6.0] for diagnosis within",
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AU - Newcomb, Craig W.

AU - Liesegang, Teresa L.

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AU - Suhler, Eric

AU - Thorne, Jennifer E.

AU - Foster, C. Stephen

AU - Jabs, Douglas A.

AU - Levy-Clarke, Grace A.

AU - Nussenblatt, Robert B.

AU - Rosenbaum, James (Jim)

AU - Sen, H. Nida

AU - Artornsombudh, Pichaporn

AU - Kothari, Srishti

AU - Kempen, John H.

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