Risk of nonspine fractures in older adults with sarcopenia, low bone mass, or both

Didier Chalhoub, Peggy M. Cawthon, Kristine E. Ensrud, Marcia L. Stefanick, Deborah M. Kado, Robert Boudreau, Susan Greenspan, Anne B. Newman, Joseph Zmuda, Eric Orwoll, Jane A. Cauley

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objectives To test the hypothesis that men and women with low bone mineral density (BMD) and sarcopenia have a higher risk of fracture than those with only one or neither conditions. Design The Osteoporotic Fractures in Men Study and the Study of Osteoporotic Fractures in women are prospective observational studies with a mean follow up of 9 (2000-2012) and 8 years (1997-2009), respectively. Setting U.S. clinical centers. Participants Men (n = 5,544; mean age 73.7) and women (n = 1,114; mean age 77.6) aged 65 and older, able to walk without assistance, and without bilateral hip replacement. Measurements Sarcopenia was defined as low appendicular lean mass plus slowness or weakness and low BMD according to the World Health Organization definition of a T-score less than -1.0. Participants were classified as having normal BMD and no sarcopenia (3,367 men, 308 women), sarcopenia only (79 men, 48 women), low BMD only (1,986 men, 626 women), and low BMD and sarcopenia (112 men, 132 women). Results Men with low BMD and sarcopenia (hazard ratio (HR)=3.79, 95% confidence interval (CI)=2.65-5.41) and men with low BMD only (HR=1.67, 95% CI=1.45-1.93) but not men with sarcopenia only (HR=1.14, 95% CI=0.62-2.09) had greater risk of fracture than men with normal BMD and no sarcopenia. Women with low BMD and sarcopenia (HR=2.27, 95% CI=1.37-3.76) and women with low BMD alone (HR=2.62, 95% CI=1.74-3.95), but not women with only sarcopenia, had greater risk of fracture than women with normal BMD and no sarcopenia. Conclusion Men with low BMD and sarcopenia are at especially high risk of fracture. Sarcopenia alone did not increase fracture risk in either group.

Original languageEnglish (US)
Pages (from-to)1733-1740
Number of pages8
JournalJournal of the American Geriatrics Society
Volume63
Issue number9
DOIs
StatePublished - Sep 1 2015

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Sarcopenia
Bone Density
Bone and Bones
Confidence Intervals
Osteoporotic Fractures
Observational Studies

Keywords

  • bone-muscle interactions
  • epidemiology
  • fracture risk assessment
  • osteoporosis
  • sarcopenia

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Chalhoub, D., Cawthon, P. M., Ensrud, K. E., Stefanick, M. L., Kado, D. M., Boudreau, R., ... Cauley, J. A. (2015). Risk of nonspine fractures in older adults with sarcopenia, low bone mass, or both. Journal of the American Geriatrics Society, 63(9), 1733-1740. https://doi.org/10.1111/jgs.13605

Risk of nonspine fractures in older adults with sarcopenia, low bone mass, or both. / Chalhoub, Didier; Cawthon, Peggy M.; Ensrud, Kristine E.; Stefanick, Marcia L.; Kado, Deborah M.; Boudreau, Robert; Greenspan, Susan; Newman, Anne B.; Zmuda, Joseph; Orwoll, Eric; Cauley, Jane A.

In: Journal of the American Geriatrics Society, Vol. 63, No. 9, 01.09.2015, p. 1733-1740.

Research output: Contribution to journalArticle

Chalhoub, D, Cawthon, PM, Ensrud, KE, Stefanick, ML, Kado, DM, Boudreau, R, Greenspan, S, Newman, AB, Zmuda, J, Orwoll, E & Cauley, JA 2015, 'Risk of nonspine fractures in older adults with sarcopenia, low bone mass, or both', Journal of the American Geriatrics Society, vol. 63, no. 9, pp. 1733-1740. https://doi.org/10.1111/jgs.13605
Chalhoub D, Cawthon PM, Ensrud KE, Stefanick ML, Kado DM, Boudreau R et al. Risk of nonspine fractures in older adults with sarcopenia, low bone mass, or both. Journal of the American Geriatrics Society. 2015 Sep 1;63(9):1733-1740. https://doi.org/10.1111/jgs.13605
Chalhoub, Didier ; Cawthon, Peggy M. ; Ensrud, Kristine E. ; Stefanick, Marcia L. ; Kado, Deborah M. ; Boudreau, Robert ; Greenspan, Susan ; Newman, Anne B. ; Zmuda, Joseph ; Orwoll, Eric ; Cauley, Jane A. / Risk of nonspine fractures in older adults with sarcopenia, low bone mass, or both. In: Journal of the American Geriatrics Society. 2015 ; Vol. 63, No. 9. pp. 1733-1740.
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abstract = "Objectives To test the hypothesis that men and women with low bone mineral density (BMD) and sarcopenia have a higher risk of fracture than those with only one or neither conditions. Design The Osteoporotic Fractures in Men Study and the Study of Osteoporotic Fractures in women are prospective observational studies with a mean follow up of 9 (2000-2012) and 8 years (1997-2009), respectively. Setting U.S. clinical centers. Participants Men (n = 5,544; mean age 73.7) and women (n = 1,114; mean age 77.6) aged 65 and older, able to walk without assistance, and without bilateral hip replacement. Measurements Sarcopenia was defined as low appendicular lean mass plus slowness or weakness and low BMD according to the World Health Organization definition of a T-score less than -1.0. Participants were classified as having normal BMD and no sarcopenia (3,367 men, 308 women), sarcopenia only (79 men, 48 women), low BMD only (1,986 men, 626 women), and low BMD and sarcopenia (112 men, 132 women). Results Men with low BMD and sarcopenia (hazard ratio (HR)=3.79, 95{\%} confidence interval (CI)=2.65-5.41) and men with low BMD only (HR=1.67, 95{\%} CI=1.45-1.93) but not men with sarcopenia only (HR=1.14, 95{\%} CI=0.62-2.09) had greater risk of fracture than men with normal BMD and no sarcopenia. Women with low BMD and sarcopenia (HR=2.27, 95{\%} CI=1.37-3.76) and women with low BMD alone (HR=2.62, 95{\%} CI=1.74-3.95), but not women with only sarcopenia, had greater risk of fracture than women with normal BMD and no sarcopenia. Conclusion Men with low BMD and sarcopenia are at especially high risk of fracture. Sarcopenia alone did not increase fracture risk in either group.",
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AU - Chalhoub, Didier

AU - Cawthon, Peggy M.

AU - Ensrud, Kristine E.

AU - Stefanick, Marcia L.

AU - Kado, Deborah M.

AU - Boudreau, Robert

AU - Greenspan, Susan

AU - Newman, Anne B.

AU - Zmuda, Joseph

AU - Orwoll, Eric

AU - Cauley, Jane A.

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N2 - Objectives To test the hypothesis that men and women with low bone mineral density (BMD) and sarcopenia have a higher risk of fracture than those with only one or neither conditions. Design The Osteoporotic Fractures in Men Study and the Study of Osteoporotic Fractures in women are prospective observational studies with a mean follow up of 9 (2000-2012) and 8 years (1997-2009), respectively. Setting U.S. clinical centers. Participants Men (n = 5,544; mean age 73.7) and women (n = 1,114; mean age 77.6) aged 65 and older, able to walk without assistance, and without bilateral hip replacement. Measurements Sarcopenia was defined as low appendicular lean mass plus slowness or weakness and low BMD according to the World Health Organization definition of a T-score less than -1.0. Participants were classified as having normal BMD and no sarcopenia (3,367 men, 308 women), sarcopenia only (79 men, 48 women), low BMD only (1,986 men, 626 women), and low BMD and sarcopenia (112 men, 132 women). Results Men with low BMD and sarcopenia (hazard ratio (HR)=3.79, 95% confidence interval (CI)=2.65-5.41) and men with low BMD only (HR=1.67, 95% CI=1.45-1.93) but not men with sarcopenia only (HR=1.14, 95% CI=0.62-2.09) had greater risk of fracture than men with normal BMD and no sarcopenia. Women with low BMD and sarcopenia (HR=2.27, 95% CI=1.37-3.76) and women with low BMD alone (HR=2.62, 95% CI=1.74-3.95), but not women with only sarcopenia, had greater risk of fracture than women with normal BMD and no sarcopenia. Conclusion Men with low BMD and sarcopenia are at especially high risk of fracture. Sarcopenia alone did not increase fracture risk in either group.

AB - Objectives To test the hypothesis that men and women with low bone mineral density (BMD) and sarcopenia have a higher risk of fracture than those with only one or neither conditions. Design The Osteoporotic Fractures in Men Study and the Study of Osteoporotic Fractures in women are prospective observational studies with a mean follow up of 9 (2000-2012) and 8 years (1997-2009), respectively. Setting U.S. clinical centers. Participants Men (n = 5,544; mean age 73.7) and women (n = 1,114; mean age 77.6) aged 65 and older, able to walk without assistance, and without bilateral hip replacement. Measurements Sarcopenia was defined as low appendicular lean mass plus slowness or weakness and low BMD according to the World Health Organization definition of a T-score less than -1.0. Participants were classified as having normal BMD and no sarcopenia (3,367 men, 308 women), sarcopenia only (79 men, 48 women), low BMD only (1,986 men, 626 women), and low BMD and sarcopenia (112 men, 132 women). Results Men with low BMD and sarcopenia (hazard ratio (HR)=3.79, 95% confidence interval (CI)=2.65-5.41) and men with low BMD only (HR=1.67, 95% CI=1.45-1.93) but not men with sarcopenia only (HR=1.14, 95% CI=0.62-2.09) had greater risk of fracture than men with normal BMD and no sarcopenia. Women with low BMD and sarcopenia (HR=2.27, 95% CI=1.37-3.76) and women with low BMD alone (HR=2.62, 95% CI=1.74-3.95), but not women with only sarcopenia, had greater risk of fracture than women with normal BMD and no sarcopenia. Conclusion Men with low BMD and sarcopenia are at especially high risk of fracture. Sarcopenia alone did not increase fracture risk in either group.

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