Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease

Hiroko Dodge, Randall (Randy) Woltjer, Jeffrey Kaye, Deniz Erten-Lyons, David A. Bennett, Lisa Silbert, David W. Fardo, Jeffrey A. Kaye, Deniz Erten Lyons, Nora Mattek, Julie A. Schneider, Lisa C. Silbert, Chengjie Xiong, Lei Yu, Frederick A. Schmitt, Richard J. Kryscio, Erin L. Abner

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: The presence of cerebrovascular pathology may increase the risk of clinical diagnosis of Alzheimer's disease (AD). Methods: We examined excess risk of incident clinical diagnosis of AD (probable and possible AD) posed by the presence of lacunes and large infarcts beyond AD pathology using data from the Statistical Modeling of Aging and Risk of Transition study, a consortium of longitudinal cohort studies with more than 2000 autopsies. We created six mutually exclusive pathology patterns combining three levels of AD pathology (low, moderate, or high AD pathology) and two levels of vascular pathology (without lacunes and large infarcts or with lacunes and/or large infarcts). Results: The coexistence of lacunes and large infarcts results in higher likelihood of clinical diagnosis of AD only when AD pathology burden is low. Discussion: Our results reinforce the diagnostic importance of AD pathology in clinical AD. Further harmonization of assessment approaches for vascular pathologies is required.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

Fingerprint

Vascular Diseases
Alzheimer Disease
Pathology
Blood Vessels
Clinical Pathology
Longitudinal Studies
Autopsy
Cohort Studies

Keywords

  • Alzheimer's disease pathology
  • Community sample
  • Population Attributable Risk%
  • SMART consortium
  • Vascular pathology

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease. / Dodge, Hiroko; Woltjer, Randall (Randy); Kaye, Jeffrey; Erten-Lyons, Deniz; Bennett, David A.; Silbert, Lisa; Fardo, David W.; Kaye, Jeffrey A.; Lyons, Deniz Erten; Mattek, Nora; Schneider, Julie A.; Silbert, Lisa C.; Xiong, Chengjie; Yu, Lei; Schmitt, Frederick A.; Kryscio, Richard J.; Abner, Erin L.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

Dodge, Hiroko ; Woltjer, Randall (Randy) ; Kaye, Jeffrey ; Erten-Lyons, Deniz ; Bennett, David A. ; Silbert, Lisa ; Fardo, David W. ; Kaye, Jeffrey A. ; Lyons, Deniz Erten ; Mattek, Nora ; Schneider, Julie A. ; Silbert, Lisa C. ; Xiong, Chengjie ; Yu, Lei ; Schmitt, Frederick A. ; Kryscio, Richard J. ; Abner, Erin L. / Risk of incident clinical diagnosis of Alzheimer's disease-type dementia attributable to pathology-confirmed vascular disease. In: Alzheimer's and Dementia. 2016.
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abstract = "Introduction: The presence of cerebrovascular pathology may increase the risk of clinical diagnosis of Alzheimer's disease (AD). Methods: We examined excess risk of incident clinical diagnosis of AD (probable and possible AD) posed by the presence of lacunes and large infarcts beyond AD pathology using data from the Statistical Modeling of Aging and Risk of Transition study, a consortium of longitudinal cohort studies with more than 2000 autopsies. We created six mutually exclusive pathology patterns combining three levels of AD pathology (low, moderate, or high AD pathology) and two levels of vascular pathology (without lacunes and large infarcts or with lacunes and/or large infarcts). Results: The coexistence of lacunes and large infarcts results in higher likelihood of clinical diagnosis of AD only when AD pathology burden is low. Discussion: Our results reinforce the diagnostic importance of AD pathology in clinical AD. Further harmonization of assessment approaches for vascular pathologies is required.",
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AU - Dodge, Hiroko

AU - Woltjer, Randall (Randy)

AU - Kaye, Jeffrey

AU - Erten-Lyons, Deniz

AU - Bennett, David A.

AU - Silbert, Lisa

AU - Fardo, David W.

AU - Kaye, Jeffrey A.

AU - Lyons, Deniz Erten

AU - Mattek, Nora

AU - Schneider, Julie A.

AU - Silbert, Lisa C.

AU - Xiong, Chengjie

AU - Yu, Lei

AU - Schmitt, Frederick A.

AU - Kryscio, Richard J.

AU - Abner, Erin L.

PY - 2016

Y1 - 2016

N2 - Introduction: The presence of cerebrovascular pathology may increase the risk of clinical diagnosis of Alzheimer's disease (AD). Methods: We examined excess risk of incident clinical diagnosis of AD (probable and possible AD) posed by the presence of lacunes and large infarcts beyond AD pathology using data from the Statistical Modeling of Aging and Risk of Transition study, a consortium of longitudinal cohort studies with more than 2000 autopsies. We created six mutually exclusive pathology patterns combining three levels of AD pathology (low, moderate, or high AD pathology) and two levels of vascular pathology (without lacunes and large infarcts or with lacunes and/or large infarcts). Results: The coexistence of lacunes and large infarcts results in higher likelihood of clinical diagnosis of AD only when AD pathology burden is low. Discussion: Our results reinforce the diagnostic importance of AD pathology in clinical AD. Further harmonization of assessment approaches for vascular pathologies is required.

AB - Introduction: The presence of cerebrovascular pathology may increase the risk of clinical diagnosis of Alzheimer's disease (AD). Methods: We examined excess risk of incident clinical diagnosis of AD (probable and possible AD) posed by the presence of lacunes and large infarcts beyond AD pathology using data from the Statistical Modeling of Aging and Risk of Transition study, a consortium of longitudinal cohort studies with more than 2000 autopsies. We created six mutually exclusive pathology patterns combining three levels of AD pathology (low, moderate, or high AD pathology) and two levels of vascular pathology (without lacunes and large infarcts or with lacunes and/or large infarcts). Results: The coexistence of lacunes and large infarcts results in higher likelihood of clinical diagnosis of AD only when AD pathology burden is low. Discussion: Our results reinforce the diagnostic importance of AD pathology in clinical AD. Further harmonization of assessment approaches for vascular pathologies is required.

KW - Alzheimer's disease pathology

KW - Community sample

KW - Population Attributable Risk%

KW - SMART consortium

KW - Vascular pathology

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