Presumed hyperkalemic cardiac arrest has been reported following revascularization of kidney grafts preserved with an intracellular electrolyte solution (Collins' solution) containing potassium, 115 meq/l. We measured serum potassium levels immediately prior to and after 45 hours and in 12 recipients of living related kidney grafts preserved with a solution containing potassium, 4 meq/L (Ringer's lactate). Following restoration of the circulation to the kidney, serum potassium levels increased a mean of 0.36±0.07 meq/L (p<0.05) and 0.14±0.08 (p value was not significant) in the recipients of Collins' and Ringer's flushed kidneys, respectively. Twenty of 21 recipients receiving Collins' flushed kidneys and four of 12 receiving Ringer's flushed kidneys required external iliac artery clamping during vascular anastomosis, rendering the leg ischemic. These 24 patients had serum potassium increases of 0.22±0.05 meq/L when circulation to the leg was restored. This was significantly greater (p<0.05) than that observed in the nine patients in whom the vascular supply to the leg was not interrupted 0.1 ± 0.05 meq/l). In the 21 recipients of kidneys flushed with Collins' solution, the total increase in serum potassium was 0.45 ± 0.08 (mean±SE) meq/l (p<0.02) of which approximately 63% resulted from Collins' solution and 37% from the ischemic leg. In the 12 recipients of kidneys flushed with Ringer's lactate, the mean increase in serum potassium was statistically not significant. Potassium infusion from a kidney flushed with Collins' solution and from the previously ischemic limb can produce an increase in potassium which may be clinically significant in patients with preexisting hyperkalemia.
|Original language||English (US)|
|Number of pages||4|
|Journal||Anesthesia and analgesia|
|State||Published - Jun 27 1980|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine