Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types

Lynn Marshall, David J. Hunter, James L. Connolly, Stuart J. Schnitt, Celia Byrne, Stephanie J. London, Graham A. Colditz

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

Epidemiological studies using the histological classification of Page for benign breast disease consistently demonstrate a positive association between atypical hyperplasia and the subsequent development of breast cancer. However, atypical hyperplasia is of either lobular or ductal types, and breast cancer risk in relation to type of atypical hyperplasia has not been studied extensively. Thus, we investigated prospectively the risk of breast cancer associated with histological subtypes of benign proliferative breast disease, including the types of atypical hyperplasia, among participants in the Nurses' Health Study who had biopsy-confirmed benign breast disease. Women who subsequently developed breast cancer were matched by year of birth and year of biopsy to participants who were free from breast cancer. Benign biopsy slides were classified according to the criteria of Page. Odds ratios (ORs) of breast cancer and 95% confidence intervals (CIs), adjusted for the matching variables and other breast cancer risk factors, were computed using unconditional logistic regression with benign nonproliferative breast disease as the referent group. Atypical ductal hyperplasia (OR = 2.4; 95% CI, 1.3- 4.5) or atypical lobular hyperplasia (OR = 5.3; 95% CI, 2.7-10.4) in a prior biopsy were associated with increased breast cancer risk. Atypical lobular hyperplasia was more strongly associated with the risk of premenopausal breast cancer (OR = 9.6; 95% CI, 3.3-27.8) than with the risk of postmenopausal breast cancer (OR = 3.7; 95% CI, 1.3-10.2). The association of atypical ductal hyperplasia and breast cancer risk varied little by menopausal status. The magnitude of breast cancer risk seems to vary according to the type of atypical hyperplasia present at biopsy.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume6
Issue number5
StatePublished - 1997
Externally publishedYes

Fingerprint

Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Hyperplasia
Breast Diseases
Odds Ratio
Confidence Intervals
Biopsy
Epidemiologic Studies
Logistic Models
Nurses

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Marshall, L., Hunter, D. J., Connolly, J. L., Schnitt, S. J., Byrne, C., London, S. J., & Colditz, G. A. (1997). Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types. Cancer Epidemiology Biomarkers and Prevention, 6(5), 297-301.

Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types. / Marshall, Lynn; Hunter, David J.; Connolly, James L.; Schnitt, Stuart J.; Byrne, Celia; London, Stephanie J.; Colditz, Graham A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 6, No. 5, 1997, p. 297-301.

Research output: Contribution to journalArticle

Marshall, L, Hunter, DJ, Connolly, JL, Schnitt, SJ, Byrne, C, London, SJ & Colditz, GA 1997, 'Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types', Cancer Epidemiology Biomarkers and Prevention, vol. 6, no. 5, pp. 297-301.
Marshall, Lynn ; Hunter, David J. ; Connolly, James L. ; Schnitt, Stuart J. ; Byrne, Celia ; London, Stephanie J. ; Colditz, Graham A. / Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types. In: Cancer Epidemiology Biomarkers and Prevention. 1997 ; Vol. 6, No. 5. pp. 297-301.
@article{255ec0d866344f40886ee92a6a1cd09d,
title = "Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types",
abstract = "Epidemiological studies using the histological classification of Page for benign breast disease consistently demonstrate a positive association between atypical hyperplasia and the subsequent development of breast cancer. However, atypical hyperplasia is of either lobular or ductal types, and breast cancer risk in relation to type of atypical hyperplasia has not been studied extensively. Thus, we investigated prospectively the risk of breast cancer associated with histological subtypes of benign proliferative breast disease, including the types of atypical hyperplasia, among participants in the Nurses' Health Study who had biopsy-confirmed benign breast disease. Women who subsequently developed breast cancer were matched by year of birth and year of biopsy to participants who were free from breast cancer. Benign biopsy slides were classified according to the criteria of Page. Odds ratios (ORs) of breast cancer and 95{\%} confidence intervals (CIs), adjusted for the matching variables and other breast cancer risk factors, were computed using unconditional logistic regression with benign nonproliferative breast disease as the referent group. Atypical ductal hyperplasia (OR = 2.4; 95{\%} CI, 1.3- 4.5) or atypical lobular hyperplasia (OR = 5.3; 95{\%} CI, 2.7-10.4) in a prior biopsy were associated with increased breast cancer risk. Atypical lobular hyperplasia was more strongly associated with the risk of premenopausal breast cancer (OR = 9.6; 95{\%} CI, 3.3-27.8) than with the risk of postmenopausal breast cancer (OR = 3.7; 95{\%} CI, 1.3-10.2). The association of atypical ductal hyperplasia and breast cancer risk varied little by menopausal status. The magnitude of breast cancer risk seems to vary according to the type of atypical hyperplasia present at biopsy.",
author = "Lynn Marshall and Hunter, {David J.} and Connolly, {James L.} and Schnitt, {Stuart J.} and Celia Byrne and London, {Stephanie J.} and Colditz, {Graham A.}",
year = "1997",
language = "English (US)",
volume = "6",
pages = "297--301",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "5",

}

TY - JOUR

T1 - Risk of breast cancer associated with atypical hyperplasia of lobular and ductal types

AU - Marshall, Lynn

AU - Hunter, David J.

AU - Connolly, James L.

AU - Schnitt, Stuart J.

AU - Byrne, Celia

AU - London, Stephanie J.

AU - Colditz, Graham A.

PY - 1997

Y1 - 1997

N2 - Epidemiological studies using the histological classification of Page for benign breast disease consistently demonstrate a positive association between atypical hyperplasia and the subsequent development of breast cancer. However, atypical hyperplasia is of either lobular or ductal types, and breast cancer risk in relation to type of atypical hyperplasia has not been studied extensively. Thus, we investigated prospectively the risk of breast cancer associated with histological subtypes of benign proliferative breast disease, including the types of atypical hyperplasia, among participants in the Nurses' Health Study who had biopsy-confirmed benign breast disease. Women who subsequently developed breast cancer were matched by year of birth and year of biopsy to participants who were free from breast cancer. Benign biopsy slides were classified according to the criteria of Page. Odds ratios (ORs) of breast cancer and 95% confidence intervals (CIs), adjusted for the matching variables and other breast cancer risk factors, were computed using unconditional logistic regression with benign nonproliferative breast disease as the referent group. Atypical ductal hyperplasia (OR = 2.4; 95% CI, 1.3- 4.5) or atypical lobular hyperplasia (OR = 5.3; 95% CI, 2.7-10.4) in a prior biopsy were associated with increased breast cancer risk. Atypical lobular hyperplasia was more strongly associated with the risk of premenopausal breast cancer (OR = 9.6; 95% CI, 3.3-27.8) than with the risk of postmenopausal breast cancer (OR = 3.7; 95% CI, 1.3-10.2). The association of atypical ductal hyperplasia and breast cancer risk varied little by menopausal status. The magnitude of breast cancer risk seems to vary according to the type of atypical hyperplasia present at biopsy.

AB - Epidemiological studies using the histological classification of Page for benign breast disease consistently demonstrate a positive association between atypical hyperplasia and the subsequent development of breast cancer. However, atypical hyperplasia is of either lobular or ductal types, and breast cancer risk in relation to type of atypical hyperplasia has not been studied extensively. Thus, we investigated prospectively the risk of breast cancer associated with histological subtypes of benign proliferative breast disease, including the types of atypical hyperplasia, among participants in the Nurses' Health Study who had biopsy-confirmed benign breast disease. Women who subsequently developed breast cancer were matched by year of birth and year of biopsy to participants who were free from breast cancer. Benign biopsy slides were classified according to the criteria of Page. Odds ratios (ORs) of breast cancer and 95% confidence intervals (CIs), adjusted for the matching variables and other breast cancer risk factors, were computed using unconditional logistic regression with benign nonproliferative breast disease as the referent group. Atypical ductal hyperplasia (OR = 2.4; 95% CI, 1.3- 4.5) or atypical lobular hyperplasia (OR = 5.3; 95% CI, 2.7-10.4) in a prior biopsy were associated with increased breast cancer risk. Atypical lobular hyperplasia was more strongly associated with the risk of premenopausal breast cancer (OR = 9.6; 95% CI, 3.3-27.8) than with the risk of postmenopausal breast cancer (OR = 3.7; 95% CI, 1.3-10.2). The association of atypical ductal hyperplasia and breast cancer risk varied little by menopausal status. The magnitude of breast cancer risk seems to vary according to the type of atypical hyperplasia present at biopsy.

UR - http://www.scopus.com/inward/record.url?scp=0030979762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030979762&partnerID=8YFLogxK

M3 - Article

C2 - 9149887

AN - SCOPUS:0030979762

VL - 6

SP - 297

EP - 301

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 5

ER -