Risk of Alzheimer's disease incidence attributable to vascular disease in the population

Hiroko Dodge, Chung Chou H Chang, Ilyas M. Kamboh, Mary Ganguli

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Although Alzheimer's disease (AD) is a neurodegenerative disorder, there is growing interest in the influence of vascular factors on its incidence. Methods: In a population-based longitudinal epidemiological study, we fit Cox proportional hazard models to examine the risk of incident dementia and AD associated with self-reported vascular disease. The population-attributable risk percent (percent of the incidence of dementia and AD in the population that would be eliminated if vascular disease was eliminated) was calculated using the adjusted hazard ratios (HR). Results: Of 822 eligible participants, 94 individuals developed incident dementia, with 79 having AD (probable/possible AD) during the follow-up period of on average 8 years. Stroke/transient ischemic attack history was associated with incident dementia (HR = 2.6) as well as AD (HR = 2.4) among non-apolipoprotein E ε4 carriers. Conclusions: At the community level, the risk of dementia could be potentially reduced by 10.8% by eliminating overt cerebrovascular disease, and the risk of AD by 9.1% for non-apolipoprotein E ε4 carriers.

Original languageEnglish (US)
Pages (from-to)356-360
Number of pages5
JournalAlzheimer's and Dementia
Volume7
Issue number3
DOIs
StatePublished - May 2011

Fingerprint

Vascular Diseases
Alzheimer Disease
Dementia
Incidence
Population
Cerebrovascular Disorders
Transient Ischemic Attack
Proportional Hazards Models
Neurodegenerative Diseases
Longitudinal Studies
Epidemiologic Studies
Stroke

Keywords

  • AD
  • APOEε4
  • Epidemiology
  • Population-Attributable Risk % (PAR%)
  • Vascular disease

ASJC Scopus subject areas

  • Health Policy
  • Epidemiology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Risk of Alzheimer's disease incidence attributable to vascular disease in the population. / Dodge, Hiroko; Chang, Chung Chou H; Kamboh, Ilyas M.; Ganguli, Mary.

In: Alzheimer's and Dementia, Vol. 7, No. 3, 05.2011, p. 356-360.

Research output: Contribution to journalArticle

Dodge, Hiroko ; Chang, Chung Chou H ; Kamboh, Ilyas M. ; Ganguli, Mary. / Risk of Alzheimer's disease incidence attributable to vascular disease in the population. In: Alzheimer's and Dementia. 2011 ; Vol. 7, No. 3. pp. 356-360.
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