Risk factors for vesicourethral anastomotic stricture after radical prostatectomy

Prodromos G. Borboroglu, John P. Sands, James L. Roberts, Christopher Amling

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Objectives. Preoperative comorbidities associated with microvascular disease may contribute to the development of bladder neck contracture (BNC) by alteration of anastomotic healing. We investigated potential risk factors for development of BNC after radical prostatectomy (RP) and reviewed management of this complication. Methods. A retrospective review of 467 consecutive patients (mean age 63.2 years) undergoing RP between 1991 and 1999 was performed. In all cases, the bladder neck was tailored to 20 to 22F in a racket handle fashion. After mucosal eversion of the reconstructed bladder neck, a mucosa-to-mucosa vesicourethral anastomosis was created over an 18 to 22F catheter using 4 to 6 anastomotic sutures. The relationship between comorbidities identified preoperatively by patient interview and medical record review (coronary artery disease [CAD], diabetes mellitus [DM], hypertension [HTN], cerebral vascular accident, chronic obstructive pulmonary disease, and smoking history) and the incidence of BNC was determined. Risk factors including prior transurethral prostatectomy (TURP), estimated blood loss (EBL), and operative time (OR time) were also evaluated. Factors were evaluated for their ability to predict BNC using both univariate and multivariate analysis. Treatment results for BNC were also assessed. Results. A total of 52 (11.1%) patients developed BNC. Current cigarette smoking resulted in a significantly higher (26%) rate of BNC (P

Original languageEnglish (US)
Pages (from-to)96-100
Number of pages5
JournalUrology
Volume56
Issue number1
DOIs
StatePublished - Jul 2000
Externally publishedYes

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Prostatectomy
Contracture
Pathologic Constriction
Urinary Bladder
Comorbidity
Mucous Membrane
Smoking
Transurethral Resection of Prostate
Aptitude
Operative Time
Chronic Obstructive Pulmonary Disease
Sutures
Accidents
Medical Records
Blood Vessels
Coronary Artery Disease
Diabetes Mellitus
Multivariate Analysis
Catheters
History

ASJC Scopus subject areas

  • Urology

Cite this

Risk factors for vesicourethral anastomotic stricture after radical prostatectomy. / Borboroglu, Prodromos G.; Sands, John P.; Roberts, James L.; Amling, Christopher.

In: Urology, Vol. 56, No. 1, 07.2000, p. 96-100.

Research output: Contribution to journalArticle

Borboroglu, Prodromos G. ; Sands, John P. ; Roberts, James L. ; Amling, Christopher. / Risk factors for vesicourethral anastomotic stricture after radical prostatectomy. In: Urology. 2000 ; Vol. 56, No. 1. pp. 96-100.
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