Risk factors for hip fracture in white men: The NHANES I epidemiologic follow-up study

Michael E. Mussolino, Anne C. Looker, Jennifer H. Madans, Jean A. Langlois, Eric Orwoll

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

This prospective population-based study assessed predictors of hip fracture risk in white men. Participants were members of the Epidemiologic Follow-up Study cohort of the First National Health and Nutrition Examination Survey, a nationally representative sample of noninstitutionalized civilians who were followed for a maximum of 22 years. A cohort of 2879 white men (2249 in the nutrition and weight-loss subsample, 1437 in the bone density subsample) aged 45-74 years at baseline (1971-1975) were observed through 1992. Ninety-four percent of the original cohort were successfully traced. Hospital records and death certificates were used to identify a total of 71 hip fracture cases (61 in the nutrition and weight-loss subsample, 26 in the bone-density subsample). Among the factors evaluated were age at baseline, previous fractures other than hip, body mass index, smoking status, alcohol consumption, nonrecreational physical activity, weight loss from maximum, calcium intake, number of calories, protein consumption, chronic disease prevalence, and phalangeal bone density. The risk adjusted relative risk (RR) of hip fracture was significantly associated with presence of one or more chronic conditions (RR = 1.91, 95% confidence interval [CI] = 1.19-3.06), weight loss from maximum ≤ 10% (RR = 2.27, 95% CI 1.13-4.59), and 1 SD change in phalangeal bone density (RR = 1.73, 95% CI 1.11-2.68). No other variables were significantly related to hip fracture risk Although based on a small number of cases, this is one of the first prospective studies to relate weight loss and bone density to hip fracture risk in men.

Original languageEnglish (US)
Pages (from-to)918-924
Number of pages7
JournalJournal of Bone and Mineral Research
Volume13
Issue number6
DOIs
StatePublished - Jun 1998

Fingerprint

Nutrition Surveys
Hip Fractures
Bone Density
Weight Loss
Confidence Intervals
Death Certificates
Hospital Records
Alcohol Drinking
Body Mass Index
Chronic Disease
Smoking
Prospective Studies
Exercise
Calcium

ASJC Scopus subject areas

  • Surgery

Cite this

Risk factors for hip fracture in white men : The NHANES I epidemiologic follow-up study. / Mussolino, Michael E.; Looker, Anne C.; Madans, Jennifer H.; Langlois, Jean A.; Orwoll, Eric.

In: Journal of Bone and Mineral Research, Vol. 13, No. 6, 06.1998, p. 918-924.

Research output: Contribution to journalArticle

Mussolino, Michael E. ; Looker, Anne C. ; Madans, Jennifer H. ; Langlois, Jean A. ; Orwoll, Eric. / Risk factors for hip fracture in white men : The NHANES I epidemiologic follow-up study. In: Journal of Bone and Mineral Research. 1998 ; Vol. 13, No. 6. pp. 918-924.
@article{fae69ec488d24e7f88b402516cb228cb,
title = "Risk factors for hip fracture in white men: The NHANES I epidemiologic follow-up study",
abstract = "This prospective population-based study assessed predictors of hip fracture risk in white men. Participants were members of the Epidemiologic Follow-up Study cohort of the First National Health and Nutrition Examination Survey, a nationally representative sample of noninstitutionalized civilians who were followed for a maximum of 22 years. A cohort of 2879 white men (2249 in the nutrition and weight-loss subsample, 1437 in the bone density subsample) aged 45-74 years at baseline (1971-1975) were observed through 1992. Ninety-four percent of the original cohort were successfully traced. Hospital records and death certificates were used to identify a total of 71 hip fracture cases (61 in the nutrition and weight-loss subsample, 26 in the bone-density subsample). Among the factors evaluated were age at baseline, previous fractures other than hip, body mass index, smoking status, alcohol consumption, nonrecreational physical activity, weight loss from maximum, calcium intake, number of calories, protein consumption, chronic disease prevalence, and phalangeal bone density. The risk adjusted relative risk (RR) of hip fracture was significantly associated with presence of one or more chronic conditions (RR = 1.91, 95{\%} confidence interval [CI] = 1.19-3.06), weight loss from maximum ≤ 10{\%} (RR = 2.27, 95{\%} CI 1.13-4.59), and 1 SD change in phalangeal bone density (RR = 1.73, 95{\%} CI 1.11-2.68). No other variables were significantly related to hip fracture risk Although based on a small number of cases, this is one of the first prospective studies to relate weight loss and bone density to hip fracture risk in men.",
author = "Mussolino, {Michael E.} and Looker, {Anne C.} and Madans, {Jennifer H.} and Langlois, {Jean A.} and Eric Orwoll",
year = "1998",
month = "6",
doi = "10.1359/jbmr.1998.13.6.918",
language = "English (US)",
volume = "13",
pages = "918--924",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Risk factors for hip fracture in white men

T2 - The NHANES I epidemiologic follow-up study

AU - Mussolino, Michael E.

AU - Looker, Anne C.

AU - Madans, Jennifer H.

AU - Langlois, Jean A.

AU - Orwoll, Eric

PY - 1998/6

Y1 - 1998/6

N2 - This prospective population-based study assessed predictors of hip fracture risk in white men. Participants were members of the Epidemiologic Follow-up Study cohort of the First National Health and Nutrition Examination Survey, a nationally representative sample of noninstitutionalized civilians who were followed for a maximum of 22 years. A cohort of 2879 white men (2249 in the nutrition and weight-loss subsample, 1437 in the bone density subsample) aged 45-74 years at baseline (1971-1975) were observed through 1992. Ninety-four percent of the original cohort were successfully traced. Hospital records and death certificates were used to identify a total of 71 hip fracture cases (61 in the nutrition and weight-loss subsample, 26 in the bone-density subsample). Among the factors evaluated were age at baseline, previous fractures other than hip, body mass index, smoking status, alcohol consumption, nonrecreational physical activity, weight loss from maximum, calcium intake, number of calories, protein consumption, chronic disease prevalence, and phalangeal bone density. The risk adjusted relative risk (RR) of hip fracture was significantly associated with presence of one or more chronic conditions (RR = 1.91, 95% confidence interval [CI] = 1.19-3.06), weight loss from maximum ≤ 10% (RR = 2.27, 95% CI 1.13-4.59), and 1 SD change in phalangeal bone density (RR = 1.73, 95% CI 1.11-2.68). No other variables were significantly related to hip fracture risk Although based on a small number of cases, this is one of the first prospective studies to relate weight loss and bone density to hip fracture risk in men.

AB - This prospective population-based study assessed predictors of hip fracture risk in white men. Participants were members of the Epidemiologic Follow-up Study cohort of the First National Health and Nutrition Examination Survey, a nationally representative sample of noninstitutionalized civilians who were followed for a maximum of 22 years. A cohort of 2879 white men (2249 in the nutrition and weight-loss subsample, 1437 in the bone density subsample) aged 45-74 years at baseline (1971-1975) were observed through 1992. Ninety-four percent of the original cohort were successfully traced. Hospital records and death certificates were used to identify a total of 71 hip fracture cases (61 in the nutrition and weight-loss subsample, 26 in the bone-density subsample). Among the factors evaluated were age at baseline, previous fractures other than hip, body mass index, smoking status, alcohol consumption, nonrecreational physical activity, weight loss from maximum, calcium intake, number of calories, protein consumption, chronic disease prevalence, and phalangeal bone density. The risk adjusted relative risk (RR) of hip fracture was significantly associated with presence of one or more chronic conditions (RR = 1.91, 95% confidence interval [CI] = 1.19-3.06), weight loss from maximum ≤ 10% (RR = 2.27, 95% CI 1.13-4.59), and 1 SD change in phalangeal bone density (RR = 1.73, 95% CI 1.11-2.68). No other variables were significantly related to hip fracture risk Although based on a small number of cases, this is one of the first prospective studies to relate weight loss and bone density to hip fracture risk in men.

UR - http://www.scopus.com/inward/record.url?scp=0031801530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031801530&partnerID=8YFLogxK

U2 - 10.1359/jbmr.1998.13.6.918

DO - 10.1359/jbmr.1998.13.6.918

M3 - Article

C2 - 9626622

AN - SCOPUS:0031801530

VL - 13

SP - 918

EP - 924

JO - Journal of Bone and Mineral Research

JF - Journal of Bone and Mineral Research

SN - 0884-0431

IS - 6

ER -