Risk factors for cervical intraepithelial neoplasm in Alaska Native women

a pilot study.

R. F. MacLehose, A. Harpster, A. P. Lanier, M. A. Schiff, K. Koehler, N. Murphy, Thomas Becker

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Although rates for invasive cervical cancer have declined over the past twenty years among Alaska Native women, they continue to show high rates of pre-invasive cervical lesions (cervical intraepithelial neoplasia, or CIN). We investigated risk factors for CIN II/III among Alaska Native women in a pilot case-control study. Cases (n = 26) included women with biopsy-proven CIN II/III, while controls (n = 52) had normal cervical epithelium. The strongest risks associated with CIN II/III were HPV infection of any type (Crude Odds Ratio [OR] 8.4, 95% Confidence Interval [CI]: 2.9-29.4), HPV 16 infection (OR 40.8, 95% CI: 9.4-176.4), and a family history of cervical dysplasia (OR 3.9, 95% CI: 1.3-11.3). We also found that use of depot-medroxy progesterone acetate was associated with CIN (OR 3.0, 95% CI: 1.1-8.5). A larger investigation would be necessary to allow adequate evaluation of these, and other, risk factors for CIN among Alaska Native women.

Original languageEnglish (US)
Pages (from-to)76-85
Number of pages10
JournalAlaska medicine
Volume41
Issue number4
StatePublished - 1999
Externally publishedYes

Fingerprint

Cervical Intraepithelial Neoplasia
Odds Ratio
Confidence Intervals
Uterine Cervical Dysplasia
Human papillomavirus 16
Infection
Uterine Cervical Neoplasms
Progesterone
Case-Control Studies
Acetates
Epithelium
Biopsy
Alaska Natives

Cite this

MacLehose, R. F., Harpster, A., Lanier, A. P., Schiff, M. A., Koehler, K., Murphy, N., & Becker, T. (1999). Risk factors for cervical intraepithelial neoplasm in Alaska Native women: a pilot study. Alaska medicine, 41(4), 76-85.

Risk factors for cervical intraepithelial neoplasm in Alaska Native women : a pilot study. / MacLehose, R. F.; Harpster, A.; Lanier, A. P.; Schiff, M. A.; Koehler, K.; Murphy, N.; Becker, Thomas.

In: Alaska medicine, Vol. 41, No. 4, 1999, p. 76-85.

Research output: Contribution to journalArticle

MacLehose, RF, Harpster, A, Lanier, AP, Schiff, MA, Koehler, K, Murphy, N & Becker, T 1999, 'Risk factors for cervical intraepithelial neoplasm in Alaska Native women: a pilot study.', Alaska medicine, vol. 41, no. 4, pp. 76-85.
MacLehose RF, Harpster A, Lanier AP, Schiff MA, Koehler K, Murphy N et al. Risk factors for cervical intraepithelial neoplasm in Alaska Native women: a pilot study. Alaska medicine. 1999;41(4):76-85.
MacLehose, R. F. ; Harpster, A. ; Lanier, A. P. ; Schiff, M. A. ; Koehler, K. ; Murphy, N. ; Becker, Thomas. / Risk factors for cervical intraepithelial neoplasm in Alaska Native women : a pilot study. In: Alaska medicine. 1999 ; Vol. 41, No. 4. pp. 76-85.
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