Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women

M. Schiff, Thomas Becker, M. Masuk, L. Van Asselt-King, C. M. Wheeler, K. K. Altobelli, C. Q. North, A. J. Nahmias

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Abstract

The authors assessed risk factors for cervical intraepithelial neoplasia (CIN) among southwestern American Indian women using case-control methods. Cases were New Mexico American Indian women with biopsyproven grade I (n = 190), grade II (n = 70), or grade III (n = 42) cervical lesions diagnosed between November 1994 and October 1997. Controls were American Indian women from the same Indian Health Service clinics with normal cervical epithelium (n = 326). All subjects underwent interviews and laboratory evaluations. Interviews focused on history of sexually transmitted diseases, sexual behavior, and cigarette smoking. Laboratory assays included polymerase chain reaction-based tests for cervical human papillomavirus infection, tests for gonorrhea and chlamydia, wet mounts, and serologic assays for antibodies to Treponema pallidum, herpes simplex virus, and hepatitis B and C viruses. In multiple logistic regression analysis, the strongest risk factors for CIN II/III among American Indian women were human papillomavirus type 16 infection (adjusted odds ratio (OR) = 7.6; 95% confidence interval (CI): 2.4, 23.2), any human papillomavirus infection (OR = 5.8; 95% CI: 3.3, 10.0), low income (OR = 3.3; 95% CI: 1.7, 6.2), and history of any sexually transmitted disease (OR = 2.0; 95% CI: 1.1, 3.5). Unlike previous research, this study found no strong associations between CIN and sexual activity or cigarette smoking.

Original languageEnglish (US)
Pages (from-to)716-726
Number of pages11
JournalAmerican Journal of Epidemiology
Volume152
Issue number8
DOIs
StatePublished - Oct 15 2000

Fingerprint

Cervical Intraepithelial Neoplasia
North American Indians
Papillomavirus Infections
Odds Ratio
Confidence Intervals
Sexually Transmitted Diseases
Sexual Behavior
United States Indian Health Service
Smoking
Interviews
Cercopithecine Herpesvirus 1
Treponema pallidum
Human papillomavirus 16
Chlamydia
Gonorrhea
Simplexvirus
Hepatitis B virus
Hepacivirus
Epithelium
Logistic Models

Keywords

  • Cervical intraepithelial neoplasia
  • Cervix dysplasia
  • Indians, North American
  • Papillomavirus, human
  • Sexually transmitted diseases

ASJC Scopus subject areas

  • Epidemiology

Cite this

Schiff, M., Becker, T., Masuk, M., Van Asselt-King, L., Wheeler, C. M., Altobelli, K. K., ... Nahmias, A. J. (2000). Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women. American Journal of Epidemiology, 152(8), 716-726. https://doi.org/10.1093/aje/152.8.716

Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women. / Schiff, M.; Becker, Thomas; Masuk, M.; Van Asselt-King, L.; Wheeler, C. M.; Altobelli, K. K.; North, C. Q.; Nahmias, A. J.

In: American Journal of Epidemiology, Vol. 152, No. 8, 15.10.2000, p. 716-726.

Research output: Contribution to journalArticle

Schiff, M, Becker, T, Masuk, M, Van Asselt-King, L, Wheeler, CM, Altobelli, KK, North, CQ & Nahmias, AJ 2000, 'Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women', American Journal of Epidemiology, vol. 152, no. 8, pp. 716-726. https://doi.org/10.1093/aje/152.8.716
Schiff, M. ; Becker, Thomas ; Masuk, M. ; Van Asselt-King, L. ; Wheeler, C. M. ; Altobelli, K. K. ; North, C. Q. ; Nahmias, A. J. / Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women. In: American Journal of Epidemiology. 2000 ; Vol. 152, No. 8. pp. 716-726.
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