Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women

Melissa Schiff, Thomas M. Becker, Mary Masuk, Linda van Asselt-King, Cosette M. Wheeler, Kathleen K. Altobelli, Charles Q. North, Andre J. Nahmias

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The authors assessed risk factors for cervical intraepithelial neoplasia (CIN) among southwestern American Indian women using case-control methods. Cases were New Mexico American Indian women with biopsyproven grade I (n = 190), grade II (n = 70), or grade III (n = 42) cervical lesions diagnosed between November 1994 and October 1997. Controls were American Indian women from the same Indian Health Service clinics with normal cervical epithelium (n = 326). All subjects underwent interviews and laboratory evaluations. Interviews focused on history of sexually transmitted diseases, sexual behavior, and cigarette smoking. Laboratory assays included polymerase chain reaction-based tests for cervical human papillomavirus infection, tests for gonorrhea and chlamydia, wet mounts, and serologic assays for antibodies to Treponema pallidum, herpes simplex virus, and hepatitis B and C viruses. In multiple logistic regression analysis, the strongest risk factors for CIN II/III among American Indian women were human papillomavirus type 16 infection (adjusted odds ratio (OR) = 7.6; 95% confidence interval (CI): 2.4, 23.2), any human papillomavirus infection (OR = 5.8; 95% CI: 3.3, 10.0), low income (OR = 3.3; 95% CI: 1.7, 6.2), and history of any sexually transmitted disease (OR = 2.0; 95% CI: 1.1, 3.5). Unlike previous research, this study found no strong associations between CIN and sexual activity or cigarette smoking.

Original languageEnglish (US)
Pages (from-to)716-726
Number of pages11
JournalAmerican journal of epidemiology
Volume152
Issue number8
DOIs
StatePublished - Oct 15 2000

Keywords

  • Cervical intraepithelial neoplasia
  • Cervix dysplasia
  • Indians, North American
  • Papillomavirus, human
  • Sexually transmitted diseases

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women'. Together they form a unique fingerprint.

  • Cite this

    Schiff, M., Becker, T. M., Masuk, M., van Asselt-King, L., Wheeler, C. M., Altobelli, K. K., North, C. Q., & Nahmias, A. J. (2000). Risk factors for cervical intraepithelial neoplasia in Southwestern American Indian women. American journal of epidemiology, 152(8), 716-726. https://doi.org/10.1093/aje/152.8.716