Risk factors associated with plasma omega-3 fatty acid levels in patients with suspected coronary artery disease

Rahul Chaudhary, Katayoon Saadin, Kevin P. Bliden, William Harris, Bao Dinh, Tushar Sharma, Udaya S. Tantry, Paul A. Gurbel

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Introduction We sought to determine the associations between plasma eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) levels and various cardiovascular risk factors and with the use of fish oil supplements (FOS). Patients and methods Patients with suspected coronary artery disease (CAD) undergoing cardiac catheterization (n=433) were studied. Serum fatty acid (FA) composition, the concentrations of lipids and biomarkers of oxidative stress, and dietary/lifestyle factors were measured. Results FOS use was associated with a higher plasma EPA+DHA levels (3.7±1.5 vs. 2.6±1.1%, p<0.0001). However, there was no relationship between FOS dose (mg/day) and EPA+DHA levels in 76 patients reporting FOS use (r=−0.21, p=0.07). Lower levels were inversely associated with risk factor profiles including lower ApoB100/ApoA1 ratios (p<0.001). Discussion and conclusions Higher EPA+DHA levels characterized patients with lower CAD risk. The lack of relations between FOS dose and plasma EPA+DHA levels likely reflects uncaptured variability in EPA+DHA content of supplements.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume113
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Keywords

  • Cardiovascular risk
  • Coronary artery disease
  • Docosahexaenoic acid
  • Eicosapentaenoic acid
  • Fish oil supplements
  • Omega-3 fatty acids

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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