Risk factors associated with major cerebrovascular complications after intracranial stenting

F. Nahab, M. J. Lynn, S. E. Kasner, M. J. Alexander, R. Klucznik, O. O. Zaidat, J. Chaloupka, Helmi Lutsep, S. Barnwell, M. Mawad, B. Lane, M. I. Chimowitz

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

BACKGROUND:: There are limited data on the relationship between patient and site characteristics and clinical outcomes after intracranial stenting. METHODS:: We performed a multivariable analysis that correlated patient and site characteristics with the occurrence of the primary endpoint (any stroke or death within 30 days of stenting or stroke in the territory of the stented artery beyond 30 days) in 160 patients enrolled in this stenting registry. All patients presented with an ischemic stroke, TIA, or other cerebral ischemic event (e.g., vertebrobasilar insufficiency) in the territory of a suspected 50-99% stenosis of a major intracranial artery while on antithrombotic therapy. RESULTS:: Cerebral angiography confirmed that 99% (158/160) of patients had a 50-99% stenosis. In multivariable analysis, the primary endpoint was associated with posterior circulation stenosis (vs anterior circulation) (hazard ratio [HR] 3.4, 95% confidence interval [CI] 1.2-9.3, p ≤ 0.018), stenting at low enrollment sites (

Original languageEnglish (US)
Pages (from-to)2014-2019
Number of pages6
JournalNeurology
Volume72
Issue number23
DOIs
StatePublished - Jun 9 2009

Fingerprint

Pathologic Constriction
Stroke
Arteries
Vertebrobasilar Insufficiency
Cerebral Angiography
Registries
Confidence Intervals
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Nahab, F., Lynn, M. J., Kasner, S. E., Alexander, M. J., Klucznik, R., Zaidat, O. O., ... Chimowitz, M. I. (2009). Risk factors associated with major cerebrovascular complications after intracranial stenting. Neurology, 72(23), 2014-2019. https://doi.org/10.1212/01.wnl.0b013e3181a1863c

Risk factors associated with major cerebrovascular complications after intracranial stenting. / Nahab, F.; Lynn, M. J.; Kasner, S. E.; Alexander, M. J.; Klucznik, R.; Zaidat, O. O.; Chaloupka, J.; Lutsep, Helmi; Barnwell, S.; Mawad, M.; Lane, B.; Chimowitz, M. I.

In: Neurology, Vol. 72, No. 23, 09.06.2009, p. 2014-2019.

Research output: Contribution to journalArticle

Nahab, F, Lynn, MJ, Kasner, SE, Alexander, MJ, Klucznik, R, Zaidat, OO, Chaloupka, J, Lutsep, H, Barnwell, S, Mawad, M, Lane, B & Chimowitz, MI 2009, 'Risk factors associated with major cerebrovascular complications after intracranial stenting', Neurology, vol. 72, no. 23, pp. 2014-2019. https://doi.org/10.1212/01.wnl.0b013e3181a1863c
Nahab F, Lynn MJ, Kasner SE, Alexander MJ, Klucznik R, Zaidat OO et al. Risk factors associated with major cerebrovascular complications after intracranial stenting. Neurology. 2009 Jun 9;72(23):2014-2019. https://doi.org/10.1212/01.wnl.0b013e3181a1863c
Nahab, F. ; Lynn, M. J. ; Kasner, S. E. ; Alexander, M. J. ; Klucznik, R. ; Zaidat, O. O. ; Chaloupka, J. ; Lutsep, Helmi ; Barnwell, S. ; Mawad, M. ; Lane, B. ; Chimowitz, M. I. / Risk factors associated with major cerebrovascular complications after intracranial stenting. In: Neurology. 2009 ; Vol. 72, No. 23. pp. 2014-2019.
@article{a9feba538ddb4c37b764590b494132e0,
title = "Risk factors associated with major cerebrovascular complications after intracranial stenting",
abstract = "BACKGROUND:: There are limited data on the relationship between patient and site characteristics and clinical outcomes after intracranial stenting. METHODS:: We performed a multivariable analysis that correlated patient and site characteristics with the occurrence of the primary endpoint (any stroke or death within 30 days of stenting or stroke in the territory of the stented artery beyond 30 days) in 160 patients enrolled in this stenting registry. All patients presented with an ischemic stroke, TIA, or other cerebral ischemic event (e.g., vertebrobasilar insufficiency) in the territory of a suspected 50-99{\%} stenosis of a major intracranial artery while on antithrombotic therapy. RESULTS:: Cerebral angiography confirmed that 99{\%} (158/160) of patients had a 50-99{\%} stenosis. In multivariable analysis, the primary endpoint was associated with posterior circulation stenosis (vs anterior circulation) (hazard ratio [HR] 3.4, 95{\%} confidence interval [CI] 1.2-9.3, p ≤ 0.018), stenting at low enrollment sites (",
author = "F. Nahab and Lynn, {M. J.} and Kasner, {S. E.} and Alexander, {M. J.} and R. Klucznik and Zaidat, {O. O.} and J. Chaloupka and Helmi Lutsep and S. Barnwell and M. Mawad and B. Lane and Chimowitz, {M. I.}",
year = "2009",
month = "6",
day = "9",
doi = "10.1212/01.wnl.0b013e3181a1863c",
language = "English (US)",
volume = "72",
pages = "2014--2019",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "23",

}

TY - JOUR

T1 - Risk factors associated with major cerebrovascular complications after intracranial stenting

AU - Nahab, F.

AU - Lynn, M. J.

AU - Kasner, S. E.

AU - Alexander, M. J.

AU - Klucznik, R.

AU - Zaidat, O. O.

AU - Chaloupka, J.

AU - Lutsep, Helmi

AU - Barnwell, S.

AU - Mawad, M.

AU - Lane, B.

AU - Chimowitz, M. I.

PY - 2009/6/9

Y1 - 2009/6/9

N2 - BACKGROUND:: There are limited data on the relationship between patient and site characteristics and clinical outcomes after intracranial stenting. METHODS:: We performed a multivariable analysis that correlated patient and site characteristics with the occurrence of the primary endpoint (any stroke or death within 30 days of stenting or stroke in the territory of the stented artery beyond 30 days) in 160 patients enrolled in this stenting registry. All patients presented with an ischemic stroke, TIA, or other cerebral ischemic event (e.g., vertebrobasilar insufficiency) in the territory of a suspected 50-99% stenosis of a major intracranial artery while on antithrombotic therapy. RESULTS:: Cerebral angiography confirmed that 99% (158/160) of patients had a 50-99% stenosis. In multivariable analysis, the primary endpoint was associated with posterior circulation stenosis (vs anterior circulation) (hazard ratio [HR] 3.4, 95% confidence interval [CI] 1.2-9.3, p ≤ 0.018), stenting at low enrollment sites (

AB - BACKGROUND:: There are limited data on the relationship between patient and site characteristics and clinical outcomes after intracranial stenting. METHODS:: We performed a multivariable analysis that correlated patient and site characteristics with the occurrence of the primary endpoint (any stroke or death within 30 days of stenting or stroke in the territory of the stented artery beyond 30 days) in 160 patients enrolled in this stenting registry. All patients presented with an ischemic stroke, TIA, or other cerebral ischemic event (e.g., vertebrobasilar insufficiency) in the territory of a suspected 50-99% stenosis of a major intracranial artery while on antithrombotic therapy. RESULTS:: Cerebral angiography confirmed that 99% (158/160) of patients had a 50-99% stenosis. In multivariable analysis, the primary endpoint was associated with posterior circulation stenosis (vs anterior circulation) (hazard ratio [HR] 3.4, 95% confidence interval [CI] 1.2-9.3, p ≤ 0.018), stenting at low enrollment sites (

UR - http://www.scopus.com/inward/record.url?scp=67649472551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649472551&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0b013e3181a1863c

DO - 10.1212/01.wnl.0b013e3181a1863c

M3 - Article

C2 - 19299309

AN - SCOPUS:67649472551

VL - 72

SP - 2014

EP - 2019

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 23

ER -