Ring-Screening to Control Endemic Transmission of Taenia solium

Seth O'Neal, Luz M. Moyano, Viterbo Ayvar, Silvia Rodriguez, Cesar Gavidia, Patricia P. Wilkins, Robert H. Gilman, Hector H. Garcia, Armando E. Gonzalez

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Taenia solium is a major cause of preventable epilepsy in developing nations. Screening and treatment of human intestinal stage infection (taeniasis) within high-risk foci may reduce transmission and prevent epilepsy by limiting human exposure to infective eggs. We piloted a ring-strategy that involves screening and treatment for taeniasis among households located nearby pigs heavily-infected with the larval stage (cysticercosis). These pigs mark areas of increased transmission and can be identified by tongue examination.

We selected two villages in northern Peru for a controlled prospective interventional cohort pilot study. In the intervention village (1,058 residents) we examined the tongues of all pigs every 4 months for nodules characteristic of cysticercosis. We then screened all residents living within 100-meters of any tongue-positive pig using enzyme-linked immunosorbent assay to detect Taenia antigens in stool. Residents with taeniasis were treated with niclosamide. In both the intervention and control (753 residents) we measured incidence of exposure by sampling the pig population every 4 months for serum antibodies against cysticercosis using enzyme-linked immunoelectrotransfer blot.

Baseline seroincidence among pigs born during the study was 22.6 cases per 100 pigs per-month (95% confidence interval [CI] 17.0–30.0) in the intervention and 18.1 (95% CI 12.7–25.9) in the control. After one year we observed a 41% reduction in seroincidence in the intervention village compared to baseline (incidence rate ratio 0.59, 95% CI 0.41–0.87) while the seroincidence in the control village remained unchanged. At study end, the prevalence of taeniasis was nearly 4 times lower in the intervention than in the control (prevalence ratio 0.28, 95% CI 0.08–0.91).

Ring-screening reduced transmission of T. solium in this pilot study and may provide an effective and practical approach for regions where resources are limited. However, this strategy requires validation in larger populations over a greater period of time.

Original languageEnglish (US)
JournalPLoS Neglected Tropical Diseases
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2014

Fingerprint

Taenia solium
Swine
Cysticercosis
Tongue
Confidence Intervals
Infection
Epilepsy
Niclosamide
Taenia
Therapeutics
Peru
Incidence
Eggs
Population
Developing Countries
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Antigens
Antibodies
Enzymes

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

O'Neal, S., Moyano, L. M., Ayvar, V., Rodriguez, S., Gavidia, C., Wilkins, P. P., ... Gonzalez, A. E. (2014). Ring-Screening to Control Endemic Transmission of Taenia solium. PLoS Neglected Tropical Diseases, 8(9). https://doi.org/10.1371/journal.pntd.0003125

Ring-Screening to Control Endemic Transmission of Taenia solium. / O'Neal, Seth; Moyano, Luz M.; Ayvar, Viterbo; Rodriguez, Silvia; Gavidia, Cesar; Wilkins, Patricia P.; Gilman, Robert H.; Garcia, Hector H.; Gonzalez, Armando E.

In: PLoS Neglected Tropical Diseases, Vol. 8, No. 9, 01.09.2014.

Research output: Contribution to journalArticle

O'Neal, S, Moyano, LM, Ayvar, V, Rodriguez, S, Gavidia, C, Wilkins, PP, Gilman, RH, Garcia, HH & Gonzalez, AE 2014, 'Ring-Screening to Control Endemic Transmission of Taenia solium', PLoS Neglected Tropical Diseases, vol. 8, no. 9. https://doi.org/10.1371/journal.pntd.0003125
O'Neal, Seth ; Moyano, Luz M. ; Ayvar, Viterbo ; Rodriguez, Silvia ; Gavidia, Cesar ; Wilkins, Patricia P. ; Gilman, Robert H. ; Garcia, Hector H. ; Gonzalez, Armando E. / Ring-Screening to Control Endemic Transmission of Taenia solium. In: PLoS Neglected Tropical Diseases. 2014 ; Vol. 8, No. 9.
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