Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension

Jens Vogel-Claussen, Jan Skrok, Monda L. Shehata, Sukhminder Singh, Christopher Sibley, Danielle M. Boyce, Noah Lechtzin, Reda E. Girgis, Steven C. Mathai, Thomas A. Goldstein, Jie Zheng, João A C Lima, David A. Bluemke, Paul M. Hassoun

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the relationships of right ventricular (RV) and left ventricular (LV) myocardial perfusion reserves with ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) by using adenosine stress perfusion cardiac magnetic resonance (MR) imaging. Materials and Methods: This HIPAA-compliant study was institutional review board approved. Twenty-five patients known or suspected to have PAH underwent right heart catheterization and adenosine stress MR imaging on the same day. Sixteen matched healthy control subjects underwent cardiac MR imaging only. RV and LV perfusion values at rest and at adenosine-induced stress were calculated by using the Fermi function model. The MR imaging-derived RV and LV functional data were calculated by using dedicated software. Statistical testing included Kruskal-Wallis tests for continuous data, Spearman rank correlation tests, and multiple linear regression analyses. Results: Seventeen of the 25 patients had PAH: 11 with sclerodermaassociated PAH, and six with idiopathic PAH. The remaining eight patients had scleroderma without PAH. The myocardial perfusion reserve indexes (MPRIs) in the PAH group (median RV MPRI, 1.7 [25th-75th percentile range, 1.3-2.0]; median LV MPRI, 1.8 [25th-75th percentile range, 1.6-2.1]) were significantly lower than those in the scleroderma non-PAH (median RV MPRI, 2.5 [25th-75th percentile range, 1.8-3.9] [P =.03]; median LV MPRI, 4.1 [25th-75th percentile range, 2.6-4.8] [P =.0003]) and control (median RV MPRI, 2.9 [25th-75th percentile range, 2.6-3.6] [P

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalRadiology
Volume258
Issue number1
DOIs
StatePublished - Jan 2011
Externally publishedYes

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Right Ventricular Function
Pulmonary Hypertension
Perfusion
Hemodynamics
Lung
Adenosine
Magnetic Resonance Imaging
Health Insurance Portability and Accountability Act
Ventricular Function
Magnetic Resonance Angiography
Research Ethics Committees
Cardiac Catheterization
Linear Models
Healthy Volunteers
Software
Regression Analysis
Hypertension

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension. / Vogel-Claussen, Jens; Skrok, Jan; Shehata, Monda L.; Singh, Sukhminder; Sibley, Christopher; Boyce, Danielle M.; Lechtzin, Noah; Girgis, Reda E.; Mathai, Steven C.; Goldstein, Thomas A.; Zheng, Jie; Lima, João A C; Bluemke, David A.; Hassoun, Paul M.

In: Radiology, Vol. 258, No. 1, 01.2011, p. 119-127.

Research output: Contribution to journalArticle

Vogel-Claussen, J, Skrok, J, Shehata, ML, Singh, S, Sibley, C, Boyce, DM, Lechtzin, N, Girgis, RE, Mathai, SC, Goldstein, TA, Zheng, J, Lima, JAC, Bluemke, DA & Hassoun, PM 2011, 'Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension', Radiology, vol. 258, no. 1, pp. 119-127. https://doi.org/10.1148/radiol.10100725
Vogel-Claussen, Jens ; Skrok, Jan ; Shehata, Monda L. ; Singh, Sukhminder ; Sibley, Christopher ; Boyce, Danielle M. ; Lechtzin, Noah ; Girgis, Reda E. ; Mathai, Steven C. ; Goldstein, Thomas A. ; Zheng, Jie ; Lima, João A C ; Bluemke, David A. ; Hassoun, Paul M. / Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension. In: Radiology. 2011 ; Vol. 258, No. 1. pp. 119-127.
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AU - Vogel-Claussen, Jens

AU - Skrok, Jan

AU - Shehata, Monda L.

AU - Singh, Sukhminder

AU - Sibley, Christopher

AU - Boyce, Danielle M.

AU - Lechtzin, Noah

AU - Girgis, Reda E.

AU - Mathai, Steven C.

AU - Goldstein, Thomas A.

AU - Zheng, Jie

AU - Lima, João A C

AU - Bluemke, David A.

AU - Hassoun, Paul M.

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N2 - Purpose: To evaluate the relationships of right ventricular (RV) and left ventricular (LV) myocardial perfusion reserves with ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) by using adenosine stress perfusion cardiac magnetic resonance (MR) imaging. Materials and Methods: This HIPAA-compliant study was institutional review board approved. Twenty-five patients known or suspected to have PAH underwent right heart catheterization and adenosine stress MR imaging on the same day. Sixteen matched healthy control subjects underwent cardiac MR imaging only. RV and LV perfusion values at rest and at adenosine-induced stress were calculated by using the Fermi function model. The MR imaging-derived RV and LV functional data were calculated by using dedicated software. Statistical testing included Kruskal-Wallis tests for continuous data, Spearman rank correlation tests, and multiple linear regression analyses. Results: Seventeen of the 25 patients had PAH: 11 with sclerodermaassociated PAH, and six with idiopathic PAH. The remaining eight patients had scleroderma without PAH. The myocardial perfusion reserve indexes (MPRIs) in the PAH group (median RV MPRI, 1.7 [25th-75th percentile range, 1.3-2.0]; median LV MPRI, 1.8 [25th-75th percentile range, 1.6-2.1]) were significantly lower than those in the scleroderma non-PAH (median RV MPRI, 2.5 [25th-75th percentile range, 1.8-3.9] [P =.03]; median LV MPRI, 4.1 [25th-75th percentile range, 2.6-4.8] [P =.0003]) and control (median RV MPRI, 2.9 [25th-75th percentile range, 2.6-3.6] [P

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