RIFM fragrance ingredient safety assessment, tetrahydro-α-pentylfurfuryl acetate, CAS Registry Number 67634-08-6

A. M. Api, D. Belsito, S. Biserta, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. A. Cancellieri, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, S. Gadhia, L. Jones, K. Joshi, A. Lapczynski, M. Lavelle, D. C. Liebler, M. NaD. O'Brien, A. Patel, T. M. Penning, G. Ritacco, F. Rodriguez-Ropero, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, F. Siddiqi, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, S. Tsang

Research output: Contribution to journalShort surveypeer-review

Abstract

The existing information supports the use of this material as described in this safety assessment. Tetrahydro-α-pentylfurfuryl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that tetrahydro-α-pentylfurfuryl acetate is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class III material, and the exposure to tetrahydro-α-pentylfurfuryl acetate is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; tetrahydro-α-pentylfurfuryl acetate is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; tetrahydro-α-pentylfurfuryl acetate was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

Original languageEnglish (US)
Article number111622
JournalFood and Chemical Toxicology
Volume144
DOIs
StatePublished - Oct 15 2020

Keywords

  • Environmental Safety
  • Genotoxicity
  • Local Respiratory Toxicity
  • Phototoxicity/Photoallergenicity
  • Repeated Dose, Developmental, and Reproductive Toxicity
  • Skin Sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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