RIFM fragrance ingredient safety assessment, propanal diethyl acetal, CAS registry number 4744-08-5

A. M. Api, D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, L. Jones, K. Joshi, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, A. Patel, T. M. PenningG. Ritacco, J. Romine, N. Sadekar, D. Salvito, T. W. Schultz, I. G. Sipes, G. Sullivan, Y. Thakkar, Y. Tokura, S. Tsang

Research output: Contribution to journalShort surveypeer-review

Abstract

There are insufficient toxicity data on the target material propanal diethyl acetal (CAS # 4744-08-5). Hence, in silico evaluation was conducted to determine read-across analogs for this material. Based on structural similarity, reactivity, metabolism data, physical–chemical properties, and expert judgment, analogs acetal (CAS # 105-57-7) and butane, 1,1'-[methylenebis(oxy)]bis- (CAS # 2568-90-3) were identified as read-across materials with sufficient data for toxicological evaluation of genotoxicity.

Original languageEnglish (US)
Article number110588
JournalFood and Chemical Toxicology
Volume130
DOIs
StatePublished - Aug 2019

Keywords

  • Environmental Safety
  • Genotoxicity
  • Local Respiratory Toxicity
  • Phototoxicity/Photoallergenicity
  • Repeated Dose, Developmental, and Reproductive Toxicity
  • Skin Sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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