RIFM fragrance ingredient safety assessment, Linalyl isovalerate, CAS Registry Number 1118-27-0

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journalShort survey

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was based on the Threshold of Toxicological Concern (TTC) of 0.03 mg/kg/day for a Cramer Class I material. The estimated systemic exposure is determined to be equal to this value while assuming 100% absorption from skin contact and inhalation. A systemic exposure at or below the TTC value is acceptable.

Original languageEnglish (US)
Pages (from-to)S88-S99
JournalFood and Chemical Toxicology
Volume84
DOIs
StatePublished - Jul 23 2015

Keywords

  • Developmental and reproductive toxicity
  • Environmental safety
  • Genotoxicity
  • Local respiratory toxicity
  • Phototoxicity/Photoallergenicity
  • Repeated dose
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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    Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, Linalyl isovalerate, CAS Registry Number 1118-27-0. Food and Chemical Toxicology, 84, S88-S99. https://doi.org/10.1016/j.fct.2015.08.025