RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, Allison Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, T. M. Penning, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journalShort survey

Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8) and cinnamic acid (CAS # 621-82-9) as suitable read across analogs, which provided a MOE > 100. The repeated dose toxicity endpoint was completed using data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Original languageEnglish (US)
Pages (from-to)S110-S118
JournalFood and Chemical Toxicology
Volume97
DOIs
StatePublished - Nov 1 2016

Fingerprint

Phototoxic Dermatitis
Fragrances
cinnamates
safety assessment
endpoints
Toxicity
Registries
ingredients
odors
Safety
Skin
toxicity
phototoxicity
developmental toxicity
Toxicology
reproductive toxicology
cinnamic acid
genotoxicity
linalool
dosage

Keywords

  • Developmental and reproductive toxicity
  • Environmental safety
  • Genotoxicit
  • Local respiratory toxicity
  • Phototoxicity/photoallergenicity
  • Repeated dose
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5. Food and Chemical Toxicology, 97, S110-S118. https://doi.org/10.1016/j.fct.2016.07.029

RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, Allison; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Penning, T. M.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S110-S118.

Research output: Contribution to journalShort survey

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, A, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Penning, TM, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5', Food and Chemical Toxicology, vol. 97, pp. S110-S118. https://doi.org/10.1016/j.fct.2016.07.029
Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, Allison ; Kromidas, L. ; La Cava, S. ; Lalko, J. F. ; Lapczynski, A. ; Liebler, D. C. ; Penning, T. M. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, linalyl cinnamate, CAS Registry Number 78-37-5. In: Food and Chemical Toxicology. 2016 ; Vol. 97. pp. S110-S118.
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AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

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