RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, J. Shen, T. W. Schultz, I. G. SipesB. Wall, D. K. Wilcox

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information.This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 15 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 10,714 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.

Original languageEnglish (US)
Pages (from-to)S25-S32
JournalFood and Chemical Toxicology
Volume84
DOIs
StatePublished - Jul 23 2015

Keywords

  • Developmental and reproductive toxicity
  • Environmental safety
  • Genotoxicity
  • Local respiratory toxicity
  • Phototoxicity/photoallergenicity
  • Repeated dose
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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    Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Shen, J., Schultz, T. W., ... Wilcox, D. K. (2015). RIFM fragrance ingredient safety assessment, Fenchyl alcohol, CAS registry number 1632-73-1. Food and Chemical Toxicology, 84, S25-S32. https://doi.org/10.1016/j.fct.2015.08.022