RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; J. F. Lalko; A. Lapczynski; D. C. Liebler; Y. Miyachi; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2015.12.013

RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, Y. Miyachi, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. SipesB. Wall, D. K. Wilcox

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Short survey › peer-review

13 Scopus citations

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 230 mg/kg/day. A gavage multigenerational continuous breeding study conducted in rats on a suitable read across analog resulted in a MOE of 12,105 while considering 22.6% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

Original language	English (US)
Pages (from-to)	S25-S37
Journal	Food and Chemical Toxicology
Volume	97
DOIs	https://doi.org/10.1016/j.fct.2015.12.013
State	Published - Nov 1 2016

Keywords

Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose
Reproductive and developmental toxicity
Skin sensitization

ASJC Scopus subject areas

Food Science
Toxicology

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10.1016/j.fct.2015.12.013

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lalko, J. F., Lapczynski, A., Liebler, D. C., Miyachi, Y., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., Shen, J., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0. Food and Chemical Toxicology, 97, S25-S37. https://doi.org/10.1016/j.fct.2015.12.013

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Miyachi, Y, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0', Food and Chemical Toxicology, vol. 97, pp. S25-S37. https://doi.org/10.1016/j.fct.2015.12.013

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abstract = "The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 230 mg/kg/day. A gavage multigenerational continuous breeding study conducted in rats on a suitable read across analog resulted in a MOE of 12,105 while considering 22.6% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.",

keywords = "Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Reproductive and developmental toxicity, Skin sensitization",

author = "Api, {A. M.} and D. Belsito and S. Bhatia and M. Bruze and P. Calow and Dagli, {M. L.} and W. Dekant and Fryer, {A. D.} and L. Kromidas and {La Cava}, S. and Lalko, {J. F.} and A. Lapczynski and Liebler, {D. C.} and Y. Miyachi and Politano, {V. T.} and G. Ritacco and D. Salvito and Schultz, {T. W.} and J. Shen and Sipes, {I. G.} and B. Wall and Wilcox, {D. K.}",

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doi = "10.1016/j.fct.2015.12.013",

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T1 - RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Miyachi, Y.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 230 mg/kg/day. A gavage multigenerational continuous breeding study conducted in rats on a suitable read across analog resulted in a MOE of 12,105 while considering 22.6% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

AB - The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 230 mg/kg/day. A gavage multigenerational continuous breeding study conducted in rats on a suitable read across analog resulted in a MOE of 12,105 while considering 22.6% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose

KW - Reproductive and developmental toxicity

KW - Skin sensitization

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U2 - 10.1016/j.fct.2015.12.013

DO - 10.1016/j.fct.2015.12.013

M3 - Short survey

C2 - 26702986

AN - SCOPUS:84952947794

SN - 0278-6915

VL - 97

SP - S25-S37

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, Eugenol, CAS Registry Number 97-53-0

Abstract

Keywords

ASJC Scopus subject areas

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