RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9

A. M. Api, D. Belsito, D. Botelho, D. Browne, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, M. Francis, A. D. Fryer, K. Joshi, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, A. PatelT. M. Penning, G. Ritacco, J. Romine, D. Salvito, T. W. Schultz, I. G. Sipes, Y. Thakkar, E. H. Theophilus, A. K. Tiethof, Y. Tokura, S. Tsang, J. Wahler

Research output: Contribution to journalShort survey

Abstract

The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.

Original languageEnglish (US)
Pages (from-to)S206-S213
JournalFood and Chemical Toxicology
Volume115
DOIs
StatePublished - May 2018

Keywords

  • Environmental safety
  • Local respiratory toxicity
  • Phototoxicity/photoallergencity
  • Repeated dose, developmental and reproductive toxicity
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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    Api, A. M., Belsito, D., Botelho, D., Browne, D., Bruze, M., Burton, G. A., Buschmann, J., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Francis, M., Fryer, A. D., Joshi, K., La Cava, S., Lapczynski, A., Liebler, D. C., O'Brien, D., Parakhia, R., ... Wahler, J. (2018). RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9. Food and Chemical Toxicology, 115, S206-S213. https://doi.org/10.1016/j.fct.2018.01.037