RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, Allison Fryer, L. Kromidas, S. La Cava, J. F. Lalko, A. Lapczynski, D. C. Liebler, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. Shen, I. G. Sipes, B. WallD. K. Wilcox

Research output: Contribution to journalShort survey

2 Citations (Scopus)

Abstract

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog benzyl acetate (CAS # 140-11-4) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the repeated dose, developmental and reproductive, and local respiratory toxicity endpoints. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Original languageEnglish (US)
Pages (from-to)S136-S146
JournalFood and Chemical Toxicology
Volume97
DOIs
StatePublished - Nov 1 2016

Fingerprint

Phototoxic Dermatitis
Fragrances
safety assessment
Butyrates
butyrates
endpoints
phototoxicity
Toxicity
Registries
ingredients
odors
toxicity
Safety
Skin
reproductive toxicology
developmental toxicity
genotoxicity
dosage
acetates
benzyl acetate

Keywords

  • Developmental and reproductive Toxicity
  • Environmental safety
  • Genotoxicity
  • Local respiratory toxicity
  • Phototoxicity/photoallergenicity
  • Repeated dose
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., ... Wilcox, D. K. (2016). RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7. Food and Chemical Toxicology, 97, S136-S146. https://doi.org/10.1016/j.fct.2016.08.007

RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7. / Api, A. M.; Belsito, D.; Bhatia, S.; Bruze, M.; Calow, P.; Dagli, M. L.; Dekant, W.; Fryer, Allison; Kromidas, L.; La Cava, S.; Lalko, J. F.; Lapczynski, A.; Liebler, D. C.; Politano, V. T.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Shen, J.; Sipes, I. G.; Wall, B.; Wilcox, D. K.

In: Food and Chemical Toxicology, Vol. 97, 01.11.2016, p. S136-S146.

Research output: Contribution to journalShort survey

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, A, Kromidas, L, La Cava, S, Lalko, JF, Lapczynski, A, Liebler, DC, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2016, 'RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7', Food and Chemical Toxicology, vol. 97, pp. S136-S146. https://doi.org/10.1016/j.fct.2016.08.007
Api, A. M. ; Belsito, D. ; Bhatia, S. ; Bruze, M. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Fryer, Allison ; Kromidas, L. ; La Cava, S. ; Lalko, J. F. ; Lapczynski, A. ; Liebler, D. C. ; Politano, V. T. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Shen, J. ; Sipes, I. G. ; Wall, B. ; Wilcox, D. K. / RIFM fragrance ingredient safety assessment, benzyl butyrate, CAS Registry Number 103-37-7. In: Food and Chemical Toxicology. 2016 ; Vol. 97. pp. S136-S146.
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AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

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AU - Lalko, J. F.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

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