RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

A. M. Api, D. Belsito, D. Botelho, D. Browne, M. Bruze, G. A. Burton, J. Buschmann, P. Calow, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, K. Joshi, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, A. PatelT. M. Penning, G. Ritacco, J. Romine, D. Salvito, T. W. Schultz, I. G. Sipes, Y. Thakkar, S. Tsang, J. Wahler

Research output: Contribution to journalShort survey

Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework

Original languageEnglish (US)
Pages (from-to)S234-S241
JournalFood and Chemical Toxicology
Volume110
DOIs
StatePublished - Dec 2017

Keywords

  • Developmental and reproductive toxicity
  • Environmental safety
  • Genotoxicity
  • Local respiratory toxicity
  • Phototoxicity/photoallergenicity
  • Repeated dose
  • Skin sensitization

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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    Api, A. M., Belsito, D., Botelho, D., Browne, D., Bruze, M., Burton, G. A., Buschmann, J., Calow, P., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Joshi, K., La Cava, S., Lapczynski, A., Liebler, D. C., O'Brien, D., Parakhia, R., ... Wahler, J. (2017). RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5. Food and Chemical Toxicology, 110, S234-S241. https://doi.org/10.1016/j.fct.2017.05.066