TY - JOUR
T1 - RIFM fragrance ingredient safety assessment, 6-nonenenitrile, (Z)- (9CI), CAS Registry Number 80639-54-9
AU - Api, A. M.
AU - Belsito, D.
AU - Biserta, S.
AU - Botelho, D.
AU - Bruze, M.
AU - Burton, G. A.
AU - Buschmann, J.
AU - Cancellieri, M. A.
AU - Dagli, M. L.
AU - Date, M.
AU - Dekant, W.
AU - Deodhar, C.
AU - Fryer, A. D.
AU - Gadhia, S.
AU - Jones, L.
AU - Joshi, K.
AU - Kumar, M.
AU - Lapczynski, A.
AU - Lavelle, M.
AU - Lee, I.
AU - Liebler, D. C.
AU - Moustakas, H.
AU - Na, M.
AU - Penning, T. M.
AU - Ritacco, G.
AU - Romine, J.
AU - Sadekar, N.
AU - Schultz, T. W.
AU - Selechnik, D.
AU - Siddiqi, F.
AU - Sipes, I. G.
AU - Sullivan, G.
AU - Thakkar, Y.
AU - Tokura, Y.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/7
Y1 - 2021/7
N2 - The existing information supports the use of this material as described in this safety assessment. 6-Nonenenitrile, (Z)- (9CI) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 3-(cis-3-hexenyloxy)propanenitrile (CAS # 142653-61-0) show that 6-nonenenitrile, (Z)- (9CI) is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 6-nonenenitrile, (Z)- (9CI) is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog 3-(cis-3-hexenyloxy)propanenitrile (CAS # 142653-61-0) show that there are no safety concerns for 6-nonenenitrile, (Z)- (9CI) for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 6-nonenenitrile, (Z)- (9CI) is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 6-nonenenitrile, (Z)- (9CI) was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
AB - The existing information supports the use of this material as described in this safety assessment. 6-Nonenenitrile, (Z)- (9CI) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 3-(cis-3-hexenyloxy)propanenitrile (CAS # 142653-61-0) show that 6-nonenenitrile, (Z)- (9CI) is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 6-nonenenitrile, (Z)- (9CI) is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog 3-(cis-3-hexenyloxy)propanenitrile (CAS # 142653-61-0) show that there are no safety concerns for 6-nonenenitrile, (Z)- (9CI) for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; 6-nonenenitrile, (Z)- (9CI) is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; 6-nonenenitrile, (Z)- (9CI) was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.
KW - And Reproductive Toxicity
KW - Developmental
KW - Environmental Safety
KW - Genotoxicity
KW - Local Respiratory Toxicity
KW - Phototoxicity/Photoallergenicity
KW - Repeated Dose
KW - Skin Sensitization
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UR - http://www.scopus.com/inward/citedby.url?scp=85104134954&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2021.112180
DO - 10.1016/j.fct.2021.112180
M3 - Short survey
C2 - 33839217
AN - SCOPUS:85104134954
SN - 0278-6915
VL - 153
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
M1 - 112180
ER -